Results 151 to 160 of about 1,772,503 (306)
Advanced Science, EarlyView.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Extending and Deepening the Analysis of Innovation Systems - with Empirical Illustrations from the DISCO-project [PDF]
Traditionally innovation system have been analysed either as rooted in the R&Dsystem or the production system. This paper suggests a broader approach to national innovation systems and analyse these as rooted in constellation of a national production ...
Bengt-Åke Lundvall +1 more
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Big ideas: innovation policy [PDF]
, 2011 In the last CentrePiece, John Van Reenen stressed the importance of competition and labour market flexibility for productivity growth. His latest in CEP's 'big ideas' series describes the impact of research on how policy-makers can influence innovation more directly - through tax credits for business spending on research and development.
openaire +1 more source
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Measuring Regional Innovative Capability [PDF]
Regional innovation environment has experienced remarkable changes in the recent decades. Innovativeness at regional level is seen as a consequence of networked co-operation in a regional innovation system, which sets demands for new kinds of regional ...
Tomi Tura, Vesa Harmaakorpi
core
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
THE TOWER OF BABEL? THE INNOVATION SYSTEM APPROACH VERSUS MAINSTREAM ECONOMICS. [PDF]
The Innovation systems (IS) approach and the system failures it identifies, play an important role in the design and legitimization of innovation policy. This paper analyses the usefulness of this concept.
Johannes Hers, Niek Nahuis
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Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Does innovation policy drive rural revitalization in China? - An empirical study based on Chinese rural areas. [PDF]
PLoS OneYing Z, Zhang C, Chen H, Cheng Z, Wu Z.
europepmc +1 more source
'Innovation policy is a team sport' - insights from non-governmental intermediaries in Canadian innovation ecosystem. [PDF]
Triple Helix (Heidelb), 2018 Tamtik M.
europepmc +1 more source