Results 161 to 170 of about 1,762,260 (306)

Quantitative evaluation of the medicine innovation policy in China: based on the PMC-Index model. [PDF]

Front Public Health
Guo D, Qi L, Song X.
europepmc   +1 more source

Political Uncertainty and Policy Innovation [PDF]

Conventional wisdom has it that outside sources of information enhance the capability of political institutions to separate selfish from benevolent incumbents.
Christos Kotsogiannis, Robert Schwager
core  

Comment on “De Novo Reconstruction of 3D Human Facial Images from DNA Sequence”

Advanced Science, EarlyView.
This comment examines AI‐driven DNA‐based facial reconstruction, focusing on the Difface model. While such technologies promise biomedical and forensic applications, they pose significant ethical, legal, and methodological challenges. We emphasize transparency, benchmarking, and rigorous validation to avoid misinterpretation and misuse.
Jennifer K. Wagner, Nina Claessens, Caitlin M. Maloney, Peter Claes   +3 more
wiley   +1 more source

Navigating the innovation policy dilemma: How subnational governments balance expenditure competition pressures and long-term innovation goals. [PDF]

Heliyon
Song W, Zhao K.
europepmc   +1 more source

Yardstick Competition and Policy Innovation [PDF]

A simple model of yardstick competition between jurisdictions is presented. Governments of jurisdictions face the alternative to choose between an old and a new policy with stochastic payoffs.
Rincke, Johannes
core  

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Maintaining innovation: How to make sewer robots and innovation policy work in Barcelona. [PDF]

Soc Stud Sci
Cuevas-Garcia C, Pepponi F, Pfotenhauer SM.   +2 more
europepmc   +1 more source

Financial Constraints and Other Obstacles: Are they a Threat to Innovation Activity? [PDF]

In this paper we examine the importance of financial and other obstacles to innovation in the Netherlands using statistical information from the CIS 3.5 innovation survey.
Mohnen, Pierre, Palm, Franz, Schim van der Loeff, Sybrand, Tiwari, Amaresh   +3 more
core  

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source