Results 41 to 50 of about 750,727 (267)

Optimization in Routing and Vehicle Selection for E-commerce Last Mile Logistics: Bibliometric Analysis

Acta Informatica Pragensia
Background: The study investigates the emerging concept of Last Mile Logistics (LML), focusing on optimization routing for e-commerce deliveries. This research addresses the growing demand for efficient delivery systems driven by the rise of online ...
Sari Andarwati Kunharyanto, Ratna Mayasari, Dili Oktaviana   +2 more
doaj   +1 more source

Process as an innovation

, 2021
The aim of the chapter is to present key essential aspects of innovation and their species diversity. Basic definition formulations are considered. The emphasis is on business process innovation. One case study of company from Bulgaria that has implemented business process innovations is described, as well as the results of the innovation changes. With
Lyubcho Varamezov, Iskra Panteleeva
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis and control of surface cracks in a B-bearing continuous casting blooms

High Temperature Materials and Processes
In this work, normal manufacture of a B-bearing steel was hampered by cracks in steel. In order to control these cracks, the formation mechanism has been examined through a comprehensive analysis of crack morphology, element segregation, high temperature
Mao Wenwen, Li Jie, Liu Yong, Yang Chengyu, Gao Yu, Xing Liyong, Liu Xianmin, Li Jie, Zhao Haitao   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Eco-efficient sea salt purification via coupled brine washing and elutriation technology: A pathway to high-purity salt for sustainable chlor-alkali industry

Environmental Challenges
High-purity sodium chloride (NaCl) is essential for sustainable chlor-alkali production (CAP). Impurities such as Mg²⁺ and Ca²⁺ in raw rock salt accelerate electrode degradation, cause membrane fouling, and reduce the electrolysis efficiency.
Badrut Tamam Ibnu Ali, Hamzah, Mochammad Ismail, Imam Wahyudi, Anwar Mustafa, Arief Syari'at, Umiati, Sih Parmiyatni, Yenni Bakhtiar, Bonny Agung Wahyuono, Hens Saputra, Irawan Santoso, Kusumawati Dewi Budiarti, Adhi Pramono, Endro Wahju Tjahjono   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet

Frontiers in Nutrition
A healthy diet helps transition individuals towards numerous long-term metabolic benefits but is challenging to maintain. Supplementation with additional whole food-based concentrates and herbs may support this shift by enhancing metabolic resilience ...
Chinmayee Panda, Ralph Kruse, Kaya Williams, Brea Nance, Maruti Gudavalli, Shirin Pourafshar, Brandon Metzger, Slavko Komarnytsky, Slavko Komarnytsky   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source