Results 131 to 140 of about 857,712 (309)

The effectiveness of champions in implementing innovations in health care: a systematic review. [PDF]

Implement Sci Commun, 2022
Santos WJ, Graham ID, Lalonde M, Demery Varin M, Squires JE.   +4 more
europepmc   +1 more source

Health innovators and the health police [PDF]

Perspectives in Public Health, 2017
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Tools for assessing the scalability of innovations in health: a systematic review. [PDF]

Health Res Policy Syst, 2022
Ben Charif A, Zomahoun HTV, Gogovor A, Abdoulaye Samri M, Massougbodji J, Wolfenden L, Ploeg J, Zwarenstein M, Milat AJ, Rheault N, Ousseine YM, Salerno J, Markle-Reid M, Légaré F.   +13 more
europepmc   +1 more source

Different views : including others in participatory health service innovation [PDF]

, 2011
We describe our experiences employing experience-based design (EBD) to improve an outpatients health service in the UK and discuss the impacts of incorporating the voices of those not directly using or working within the service. We suggest that such new
Bowen, Simon, Cobb, Mark, Dearden, Andy, Wolstenholme, Dan   +3 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Training and support for the role of facilitator in implementation of innovations in health and community care: a scoping review protocol. [PDF]

Syst Rev, 2023
Tistad M, Bergström A, Elf M, Eriksson L, Gustavsson C, Göras C, Harvey G, Källberg AS, Rudman A, Unbeck M, Wallin L.   +10 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Leveling up engagement: gamification’s role in creating immersive online events

Smart Learning Environments
Virtual conferences can be easily accessed, promotes audience diversity, and leads to cost reduction. However, motivation and social interaction need amelioration.
Samuel I. M. Horita, Beatriz M. S. Gonzaga, Renata M. F. Mélo, Aline B. M. Rodrigues, Aline T. Ferreira, Andreon S. M. Silva, Anne C. S. B. Marcos, Giovane F. S. Junior, Hugo A. S. Souza, João P. S. Oliveira-Correia, Lorrane A. Pereira, Mayara M. L. Carvalho, Norma C. C. Brandão, Raissa S. L. Rosa, Thiago M. Ribeiro, Yuli R. M. Souza, Mariana Alberti Gonçalves, Roberto R. Ferreira, Ingo Riederer, Andrea Henriques Pons, Luciana R. Garzoni, Tania C. Araujo-Jorge, Clélia C. Mello-Silva   +22 more
doaj   +1 more source

Innovations in Health Professionals' Education; the 'Video Case Scenario' or MOSCE. [PDF]

Indian J Otolaryngol Head Neck Surg, 2022
Radhakrishnan V, Das Poduval J.
europepmc   +1 more source