Results 21 to 30 of about 327 (122)
Regional effects of gantenerumab on neuroimaging biomarkers in the DIAN‐TU‐001 trial
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION
Monoclonal anti‐amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose metabolism, and atrophy in trial participants with dominantly inherited Alzheimer's disease (DIAD). METHODS
In the DIAN‐TU‐001 Austin McCullough, Charles D. Chen, Brian A. Gordon, Nelly Joseph‐Mathurin, Clifford R. Jack Jr, Robert Koeppe, Russ Hornbeck, Deborah Koudelis, Nicole S. McKay, Diana A. Hobbs, Shaney Flores, Sarah J. Keefe, Neelum T. Aggarwal, Ricardo F. Allegri, Sarah B. Berman, Thomas Bird, Sandra E. Black, William S. Brooks, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Nick C. Fox, Serge Gauthier, Lawrence S. Honig, Ging‐Yuek Hsiung, Mathias Jucker, Johannes Levin, Mario Masellis, Colin Masters, Patricio Chrem Mendez, John M. Ringman, B. Joy Snider, Stephen Salloway, Peter R. Schofield, Hiroyuki Shimada, Kazushi Suzuki, Christopher H. van Dyck, Gregory Klein, David B. Clifford, Carlos Cruchaga, Jason Hassenstab, Yan Li, Eric McDade, Susan Mills, John C. Morris, Richard J. Perrin, Charlene Supnet‐Bell, Guoqiao Wang, Chengjie Xiong, Randall J. Bateman, Tammie L. S. Benzinger, for the DIAN‐TU Study Team +51 morewiley +1 more sourceAlzheimer's disease and its co‐pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of APOE ε4
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION
In neurodegenerative dementias, the co‐occurrence and interaction of amyloid β peptide (Aβ), tau pathology, and other pathological lesions confound their individual contributions to neurodegeneration and their modulation by risk factors.Klara Gawor, Sam Verrept, Geethika Arekatla, David Wouters, Alicja Ronisz, Moritz Hecht, Celeste Laureyssen, Helena Ver Donck, Bas Lahaije, Simona Ospitalieri, Mathieu Vandenbulcke, Markus Otto, Christine A. F. von Arnim, Estifanos Ghebremedhin, Bernard Hanseeuw, Rik Vandenberghe, Matthew Blaschko, Alejandro Sifrim, Kristel Sleegers, Dietmar Rudolf Thal, Sandra O. Tomé +20 morewiley +1 more sourceSafety considerations of semaglutide in the potential treatment of Alzheimer's disease: A pooled analysis of semaglutide in adults aged ≥ 65 years
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 11, Issue 2, April-June 2025.Abstract INTRODUCTION
The evoke/evoke+ trials are investigating semaglutide in a population with early Alzheimer's disease (AD). Specific analyses of semaglutide safety data in older adults are limited; therefore, in the current analysis, we aimed to evaluate safety considerations with semaglutide in adults ≥ 65 years.Marwan Sabbagh, Cristina Boschini, Sharon Cohen, Magnus Fugger, Frank Jessen, Sune Dandanell, Sue D. Pedersen, Luis Rafael Solís Tarazona, Vanita R. Aroda +8 morewiley +1 more sourceTree diversity shapes the spectral signature of light transmittance in developing forests
Ecology, Volume 106, Issue 3, March 2025.Abstract
Greater tree diversity often increases forest productivity by increasing the fraction of light captured and the effectiveness of light use at the community scale. However, light may shape forest function not only as a source of energy or a cause of stress but also as a context cue: Plant photoreceptors can detect specific wavelengths of light, Laura J. Williams, Kyle R. Kovach, J. Antonio Guzmán Q., Artur Stefanski, Raimundo Bermudez, Ethan E. Butler, Domitille Coq‐‐Etchegaray, Catherine Glenn‐Stone, Peter Hajek, Johanna Klama, Belinda E. Medlyn, Christian Messier, Aboubakr Moradi, Alain Paquette, Maria H. Park, Michael Scherer‐Lorenzen, Philip A. Townsend, Peter B. Reich, Jeannine Cavender‐Bares, Meredith C. Schuman +19 morewiley +1 more sourceEuropean guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence‐based recommendations
United European Gastroenterology Journal, Volume 13, Issue 1, Page 125-172, February 2025.Abstract
Pancreatic exocrine insufficiency (PEI) is defined as a reduction in pancreatic exocrine secretion below the level that allows the normal digestion of nutrients. Pancreatic disease and surgery are the main causes of PEI. However, other conditions and upper gastrointestinal surgery can also affect the digestive function of the pancreas. PEI can J. Enrique Dominguez‐Muñoz, Miroslav Vujasinovic, Daniel de la Iglesia, Djuna Cahen, Gabriele Capurso, Natalya Gubergrits, Peter Hegyi, Pali Hungin, Johann Ockenga, Salvatore Paiella, Lukas Perkhofer, Vinciane Rebours, Jonas Rosendahl, Roberto Salvia, Isabelle Scheers, Andrea Szentesi, Stefanos Bonovas, Daniele Piovani, J. Matthias Löhr, on behalf of the European PEI Multidisciplinary Group, Hana Algül, Livia Archibugi, Marianna Arvanitakis, Sorin Barbu, Georg Beyer, Mihailo Bezmarevic, Frank Bodewes, Marja A. Boermeester, Dmitry Bordin, Marco Bruno, Güralp Ceyhan, Laszlo Czako, Ferdinando D'Amico, Enrique De Madaria, Julian De Martino, Pierre H. Deprez, Christos Dervenis, Petr Dité, Asbjørn Drewes, Sinead N. Duggan, Deniz Duman, Trond Engjom, Nils Ewald, Ovidiu Fabian, Pierluigi Fracasso, Helmut Friess, Jens Brøndum Frøkjær, Luca Frulloni, Sebastien Gaujoux, Cristian Gheorghe, Sophie Gohy, Philip Hardt, Truls Hauge, Andrew Hopper, Julio Iglesias‐Garcia, Jutta Keller, Mariia Kiriukova, Jörg Kleeff, Alexander Kleger, Andrea Laghi, José Larino‐Noia, Johanna Laukkarinen, John Leeds, Björn Lindkvist, Etna Masip, Giovanni Marchegiani, Amir Mari, Emma Martinez‐Moneo, Julia Mayerle, Anders Molven, Alexey Okhlobystin, Nikola Panic, Andrea Parniczky, Raffaele Pezzilli, Mary Phillips, Goran Poropat, Jelena Rakic Matic, Keith Roberts, Stuart Robinson, Vasile Sandru, Alain Sauvanet, Alexander Schneider, Oleg Shvets, Serena Stigliano, Davor Stimac, Oliver Strobel, Hester Timmerhuis, Mihaela Udrescu, Szilard Vancsa, Vicki Veness, Michael Wilschanski, Heiko Witt +91 morewiley +1 more sourceBarriers and Facilitators—Lessons Learned From a Randomised Trial to Implement Clinical Practice Guidelines for the Prevention of Coercion in Psychiatry
International Journal of Mental Health Nursing, Volume 34, Issue 1, February 2025.ABSTRACT
The PreVCo study (‘Prevention of Violence and Coercion’) investigated the effects of a structured programme for the implementation of guideline recommendations for the management of aggression and the prevention of violence and coercion in psychiatric hospitals in a multicentre randomised controlled trial with 55 participating wards.Susanne Jaeger, Marie Kampmann, Johanna Baumgardt, Andreas Bechdolf, Felix Bühling‐Schindowski, Celline Cole, Erich Flammer, Julia Junghanss, Tilman Steinert, Lieselotte Mahler, Dorothea Sauter, Angelika Vandamme, Sophie Hirsch +12 morewiley +1 more sourceThe Role of Atrial Fibrillation and Oral Anticoagulation Status in Health‐Related Quality of Life 12 Months After Ischemic Stroke or TIA
Brain and Behavior, Volume 15, Issue 1, January 2025.This post‐hoc analysis of the prospective MonDAFIS study (NCT02204267) analyzed whether oral anticoagulation (OAC) and symptom severity of atrial fibrillation (AF) are associated with health‐related quality of life (HRQOL) in stroke patients with newly diagnosed AF. HRQOL was examined using EQ‐index at baseline and 12 months in 2,540 patients. Patients Manuel C. Olma, Lena Steindorf‐Sabath, Serdar Tütüncü, Claudia Kunze, Cornelia Fiessler, Paulus Kirchhof, Joanna Dietzel, Johannes Schurig, Patrick Oschmann, Ludwig Niehaus, Christian Urbanek, Götz Thomalla, Darius G. Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler, Matthias Endres, for the MonDAFIS Investigators +19 morewiley +1 more sourceFrequency and clinical associations of common mental disorders in adults with high‐grade glioma—A multicenter study
Cancer, Volume 131, Issue 1, 1 January 2025.Abstract Background
One third of adults with cancer suffer from common mental disorders in addition to their malignant disease. However, it is unknown whether this proportion is the same in patients who have brain tumors and which factors modulate the risk for psychiatric comorbidity.Susanne Singer, Melanie Schranz, Melina Hippler, Robert Kuchen, Carolin Weiß Lucas, Jürgen Meixensberger, Michael Karl Fehrenbach, Naureen Keric, Meike Mitsdoerffer, Jens Gempt, Jan Coburger, Almuth Friederike Kessler, Jens Wehinger, Martin Misch, Julia Onken, Marion Rapp, Martin Voß, Minou Nadji‐Ohl, Marcus Mehlitz, Marcos Tatagiba, Ghazaleh Tabatabai, Mirjam Renovanz +21 morewiley +1 more source
