Results 51 to 60 of about 786 (165)
Mixed-methods evaluation of a structured primary care programme for children and adolescents with mental health problems (PrimA-QuO): a study protocol
BMJ Open, 2021 Introduction More than 17% of German children and adolescents have clinically relevant mental health problems (MHP). Typically, general paediatricians are often the first contact for children with MHP, and referrals to specialised care tend to be the ...Martin Lang, Eva Grill, Otto Laub, Lars Schwettmann, Verena Loidl, Siona Decke, Karina Hamacher, Pavo Marijic, Monika Murawski +8 moredoaj +1 more sourceCost‐Effectiveness of Family Conferences to Reduce Polypharmacy in Frail Older Adults
Journal of the American Geriatrics Society, Volume 73, Issue 10, Page 3009-3020, October 2025.ABSTRACT Background
Cost‐effectiveness of family conferences on deprescribing with joint prioritization of treatment goals in primary care has not been investigated so far. We assessed cost‐effectiveness in the cluster‐randomized controlled COFRAIL trial conducted with general practitioners and 521 older frail patients with polypharmacy cared for at ...Joseph Montalbo, Charalabos‐Markos Dintsios, Jens Abraham, Eva Drewelow, Manuela Ritzke, Achim Mortsiefer, Birgitt Wiese, Petra Thürmann, Stefan Wilm, Andrea Icks, COFRAIL study group +10 morewiley +1 more sourceEffect of the addition of a mental health specialist for evaluation of undiagnosed patients in centres for rare diseases (ZSE-DUO): a prospective, controlled trial with a two-phase cohort designResearch in context
EClinicalMedicine, 2023 Summary: Background: People with complex symptomatology but unclear diagnosis presenting to a centre for rare diseases (CRD) may present with mental (co-)morbidity.Helge Hebestreit, Anne-Marie Lapstich, Lilly Brandstetter, Christian Krauth, Jürgen Deckert, Kirsten Haas, Lisa Pfister, Stefanie Witt, Christopher Schippers, Jan Dieris-Hirche, Tim Maisch, Oliver Tüscher, Lavinia Bârlescu, Alexandra Berger, Mark Berneburg, Vanessa Britz, Anna Deibele, Holm Graeßner, Harald Gündel, Gereon Heuft, Thomas Lücke, Christine Mundlos, Julia Quitmann, Frank Rutsch, Katharina Schubert, Jörg Bernhard Schulz, Susann Schweiger, Cornelia Zeidler, Lena Zeltner, Martina de Zwaan, Federica Akkaya, Christine Babka, Lisa Bannert, Anja Bärsch-Michelmann, Leonie Böhm, Folke Brinkmann, Monika Bullinger, Holger Cario, Moritz de Greck, Klaus-Michael Debatin, Katrin Dillmann-Jehn, Jutta Eymann, Julia Frisch, Anja Glode, Vega Gödecke, Corinna Grasemann, Eva Grauer, Astrid Haas, Lea Haisch, Isabell, Heinrich, Melissa Held, Julia Hennermann, Stephan Herpertz, Anne Herrmann-Werner, Julian Hett, Peter Heuschmann, Bettina Hilbig, Laura Holthöfer, Christiane Imhof, Florian Junne, Jan Kassubek, Kevin-Thomas Koschitzki, Heike Krassort, Birgit Kropff, Julia Kuhn, Philipp Latzko, Thomas Loew, Albert C. Ludolph, Torsten Meyer, Isabell Meyer dos Santos, Klaus Mohnike, Martina Monninger, Martin Mücke, Susanne Müller, Thomas Musacchio, Margret Nießen, Mariel Nöhre, Stephan Ott, Andrea Petermann-Meyer, Christina Pfeifer-Duck, Lea-Sophie Piduhn, Carina Rampp, Olaf Rieß, Kristina Schaubert, Annika Schmidt, Simone Schneider, Ludger Schoels, Martina Schwalba, Udo Selig, Alexandra Sroka, Toni Steinbüchel, Sebastian Stösser, Steffi Suchant, Kathrin Ungethüm, Matthias Vogel, Daniela Volk, Christoph Vollmuth, Solange Volnov, Thomas O.F. Wagner, Sabrina Walter, Bodo Warrings, Kamil Zajt, Karola Zenker, David Zhang, Stephan Zipfel, Helge Hebestreit, Anne-Marie Lapstich, Lilly Brandstetter, Christian Krauth, Jürgen Deckert, Kirsten Haas, Lisa Pfister, Stefanie Witt, Christopher Schippers, Jan Dieris-Hirche, Tim Maisch, Oliver Tüscher, Lavinia Aurelia Bârlescu, Alexandra Berger, Mark Berneburg, Vanessa Britz, Anna Deibele, Holm Graeßner, Harald Gündel, Gereon Heuft, Thomas Lücke, Christine Mundlos, Julia Hannah Quitmann, Frank Rutsch, Katharina Schubert, Jörg B. Schulz, Susann Schweiger, Cornelia Zeidler, Lena Margarete Zeltner, Martina de Zwaan +135 moredoaj +1 more sourceTwo‐year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy
Epilepsia, Volume 66, Issue 9, Page 3242-3253, September 2025.Abstract Objective
This study was undertaken to report on the long‐term safety and efficacy of epicranial focal cortex stimulation (FCS) using the EASEE device as adjunctive neuromodulatory therapy in improving seizure control in adults with pharmacoresistant epilepsy originating from one predominant epileptogenic zone.Andreas Schulze‐Bonhage, Martin Hirsch, Susanne Knake, Ann Mertens, Michael Rademacher, Elisabeth Kaufmann, Josua Kegele, Carolin Jenkner, Volker Coenen, Martin Glaser, Sergiu Groppa, Yaroslav Winter, for the EASEE Study Group +12 morewiley +1 more sourceRegional effects of gantenerumab on neuroimaging biomarkers in the DIAN‐TU‐001 trial
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION
Monoclonal anti‐amyloid therapies are now accessible, but how these treatments influence changes within the brain is still not clear. We investigated overall and regional change in amyloid removal, glucose metabolism, and atrophy in trial participants with dominantly inherited Alzheimer's disease (DIAD). METHODS
In the DIAN‐TU‐001 Austin McCullough, Charles D. Chen, Brian A. Gordon, Nelly Joseph‐Mathurin, Clifford R. Jack Jr, Robert Koeppe, Russ Hornbeck, Deborah Koudelis, Nicole S. McKay, Diana A. Hobbs, Shaney Flores, Sarah J. Keefe, Neelum T. Aggarwal, Ricardo F. Allegri, Sarah B. Berman, Thomas Bird, Sandra E. Black, William S. Brooks, Jasmeer P. Chhatwal, Gregory S. Day, Martin R. Farlow, Nick C. Fox, Serge Gauthier, Lawrence S. Honig, Ging‐Yuek Hsiung, Mathias Jucker, Johannes Levin, Mario Masellis, Colin Masters, Patricio Chrem Mendez, John M. Ringman, B. Joy Snider, Stephen Salloway, Peter R. Schofield, Hiroyuki Shimada, Kazushi Suzuki, Christopher H. van Dyck, Gregory Klein, David B. Clifford, Carlos Cruchaga, Jason Hassenstab, Yan Li, Eric McDade, Susan Mills, John C. Morris, Richard J. Perrin, Charlene Supnet‐Bell, Guoqiao Wang, Chengjie Xiong, Randall J. Bateman, Tammie L. S. Benzinger, for the DIAN‐TU Study Team +51 morewiley +1 more sourceAlzheimer's disease and its co‐pathologies: Implications for hippocampal degeneration, cognitive decline, and the role of APOE ε4
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION
In neurodegenerative dementias, the co‐occurrence and interaction of amyloid β peptide (Aβ), tau pathology, and other pathological lesions confound their individual contributions to neurodegeneration and their modulation by risk factors.Klara Gawor, Sam Verrept, Geethika Arekatla, David Wouters, Alicja Ronisz, Moritz Hecht, Celeste Laureyssen, Helena Ver Donck, Bas Lahaije, Simona Ospitalieri, Mathieu Vandenbulcke, Markus Otto, Christine A. F. von Arnim, Estifanos Ghebremedhin, Bernard Hanseeuw, Rik Vandenberghe, Matthew Blaschko, Alejandro Sifrim, Kristel Sleegers, Dietmar Rudolf Thal, Sandra O. Tomé +20 morewiley +1 more sourceEvaluation of the Health‐Related Quality of Life and Mental Health of Parents With Children and Adolescents With a Rare Disease Based on the Results of a Randomized Controlled Trial to Investigate a Family‐Based Intervention and an Online Intervention for Affected Families (CARE‐FAM‐NET)
Family Process, Volume 64, Issue 2, June 2025.ABSTRACT
Parents caring for children with rare diseases are more impaired regarding health‐related quality of life (HRQoL) and mental health than healthy controls and norm data. To address the research gap in psychological care for these parents, this study evaluates the effectiveness of two family‐based interventions.Antonia Steinberg, Johannes Boettcher, Anna Leidger, Ania C. Muntau, Jonas Denecke, Nicole Kaiser, Anne Daubmann, Antonia Zapf, Karl Wegscheider, Ann Kathrin Ozga, Anna Isabella Suling, Monika Bullinger, Julia Quitmann, Jörg Dirmaier, Stefanie Witt, Farhad Rezvani, Christine Mundlos, Lisa Biehl, Miriam Rassenhofer, Jörg M. Fegert, Dunja Tutus, Gerald Willms, Jan Zeidler, Nicolas Pardey, Johann‐Matthias Graf von der Schulenburg, Silke Wiegand‐Grefe +25 morewiley +1 more source
