A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Stormwater Management BMP Report and Website: Innovative Stormwater Treatment Technologies BMP Manual [PDF]
, 2003 The New Hampshire Department of Environmental Services (DES) received money in 2001 from the New Hampshire Estuaries Project (NHEP) to create a manual and a website of Innovative Stormwater Treatment Technology Best Management Practices.
Couture, Steve
core +2 more sources
Mexican art exhibitions in New York as cultural diplomacy, 1928-1932 [PDF]
, 2016 In the aftermath of the 1910 Mexican Revolution, the postrevolutionary state launched an innovative campaign that exported the country’s emerging art and culture, which glorified its indigenous roots. The strategy of expanding its nation-building project
Rendon, Darcy
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
An Innovative Approach to Delivering a Family-Based Intervention to Address Parental Alcohol Misuse: Qualitative Findings from a Pilot Project [PDF]
, 2022 Hayley Alderson +4 more
openalex +1 more source
TINA Project: a project for innovative grandchildren and grandparents [PDF]
, 2011 O projecto TINA (Tecnologias de Informação para Netos e Avós) é uma iniciativa do departamento de Tecnologia Educativa e Gestão da Informação da Escola Superior de Educação (ESE) do Instituto Politécnico de Bragança (IPB) que tem como principais ...
Gonçalves, Vitor +1 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
IMPROVEMENT OF METHODS FOR EVALUATING THE INNOVATIVE PROJECTS EFFECTIVENESS
Вестник университета, 2018 The necessity of improving the methods of evaluating innovative projects, tak-ing into account the specifics and uncertainty of the innovative project connected with realization and other risks, were substantiated. Interpretations of the concepts of inno-
A. Kudriashova
doaj +1 more source
Ekonomika Nauki, 2020 The achieved and documented innovative readiness levels of PING/TPRL in implemented or current scientific/innovative projects are proposed to use for the digital assessment of the scientific and technical competencies of the researchers/project teams ...
E. A. Ilyina +2 more
doaj +1 more source
Approaches to Evaluate the Effectiveness of the Institutions of Innovative Environment [PDF]
, 2012 Purpose of the research: to study the problem of evaluating the effectiveness of innovative environment institutions, and to define the possible approaches to build a methodology for assessing the effectiveness.
Islamutdinov, Vadim
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