Results 131 to 140 of about 2,637,941 (347)
Development of a New Innovative Teaching Method Using a Comprehensive Approach: A Survey of Students' Opinion [PDF]
Biomedical Journal of Scientific & Technical Research, 2018 Comprehensive teaching methods have been evaluated by many health professional colleges and universities for a number of years...
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
PROMOTING SUSTAINABLE INSECT MANAGEMENT STRATEGIES: LEARNING FROM ORGANIC FARMERS [PDF]
Organic farmers are dependent on alternative, biology-based insect control methods and are innovative in their on-farm experimentation with new strategies.
Lohr, Luanne, Park, Timothy A.
core +1 more source
The early years of innovative approaches to youth information and counselling [PDF]
, 2012 This chapter focuses on the innovative services set up for the specific purpose of giving social support to young people by means of information and counselling in youth information and counselling services.
Faché, Willy
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Meeting the Challenges of an Aging Population with Success [PDF]
, 2015 With 117,099 people over the age of 65, Franklin County has the second-highest number of seniors among all Ohio counties. Projection data from the Ohio Department of Development indicates that Franklin County's 65-and-over population will grow to 224,340
Christy Rogers +5 more
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Competitive Advantage Achievement through Innovation and Knowledge [PDF]
Journal of Competitiveness, 2013 In today’s highly competitive environment the goal of each organisation is to defeat competition and win new customers. Individuals who are holders of knowledge represent a tool for the generation of innovations.
Urbancova Hana
doaj
Innovation, skills and performance in the downturn: an analysis of the UK innovation survey 2011 [PDF]
, 2014 The link between firms’ innovation performance and economic cycles, especially major downturns such as that of 2008-10, is a matter of great policy significance, but is relatively under-researched at least at the level of micro data on business ...
Frenz, Marion, Lambert, Ray
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