Results 141 to 150 of about 2,637,941 (347)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Analysis and Use of Information and Communication Tools in Economics of Climate Change [PDF]

open access: yes
The use of Information and Communication Technologies (ICT) in the context of climate change is of great importance in the scientific community, but can also play an important role in the policy context.
Aline Chiabai
core   +1 more source

Determining the factor structure of an integrated innovation model [PDF]

open access: yes, 2009
This paper reports on elemental factor analyses of the innovativeness study in the Turkish manufacturing industry, drawing on a sample of 184 manufacturing firms.
Alpkan, Lutfihak   +7 more
core  

An Innovative Hybrid Neuro-wavelet Method for Reconstruction of Missing Data in Astronomical Photometric Surveys

open access: yes, 2012
The investigation of solar-like oscillations for probing the star interiors has encountered a tremendous growth in the last decade. For ground based observations the most important difficulties in properly identifying the true oscillation frequencies of the stars are produced by the gaps in the observation time-series and the presence of atmospheric ...
CAPIZZI, GIACOMO   +2 more
openaire   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Locating image presentation technology within pedagogic practice [PDF]

open access: yes, 2010
This article presents data gathered through a University for the Creative Arts Learning and Teaching Research Grant (2009-2010); including a study of existing image presentation tools, both digital and non-digital; and analysis of data from four ...
Gramstadt, Marie-Therese
core   +1 more source

A Survey of Deepfake Detection Methods: Innovations, Accuracy, and Future Directions

open access: yesINTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
Deepfake technology has emerged as a significant challenge in digital media, posing risks related to misinformation and identity theft. This paper provides a comprehensive review of deepfake detection techniques, highlighting advancements in traditional machine learning, deep learning models, hybrid approaches, and attention mechanisms. We evaluate the
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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