Results 71 to 80 of about 2,535,717 (310)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Introduction to TIPS: a theory for creative design [PDF]
, 1995 A highly intriguing problem in combining artificial intelligence and engineering design is automation of the creative and innovative phases of the design process.
Mars, N.J.I. +2 more
core +4 more sources
Enterprise Systems and Innovations [PDF]
SSRN Electronic Journal, 2009 This paper analyzes the relationship between the three main enterprise systems (Enterprise Resource Planning (ERP), Supply Chain Management (SCM), Customer Relationship Management (CRM)) and firms’ innovational performance. It studies whether the enterprise systems have impacts on process as well as product innovations.
openaire +5 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Regulation system study for innovative communication services [PDF]
The change in the telecommunication market can be explained with the change within the traditional telecommunication services and the introduction of new innovative services.
Hong, Soonho
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
ROLE OF INNOVATIVE CLUSTERS IN DEVELOPMENT OF NATIONAL ECONOMY OF THE USA
Вестник университета, 2019 At the present stage the innovative system of the USA is one of the most developed in the world, and realization of cluster approach has played a significant role in development of this system.
A. Akopyan
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Вестник университета, 2019 Organization and developments of clusters in economies of the countries of the European Union (EU) was widely adopted in spite of the fact that approach to a clustering of economy and innovative system in these countries began to be applied later, than ...
A. Akopyan
doaj