Results 121 to 130 of about 2,116,504 (346)
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Global patterns of renewable energy innovation, 1990–2009 [PDF]
, 2013 Cost-effective approaches to mitigating climate change depend on advances in clean energy technologies, such as solar and wind power. Given increased technology innovation in developing countries, led by China, we focus our attention on global patterns ...
Bayer, Patrick +2 more
core +2 more sources
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Novelty of product innovation : the role of different networks [PDF]
, 2005 In the current competitive scenario, firms are driven to introduce products with a higher degree of novelty. Consequently, there is a growing need to understand the critical success factors behind radical innovation.
Nieto Sánchez, María Jesús +1 more
core +1 more source
Innovative Mobility: Carsharing Outlook Carsharing Market Overview, Analysis, And Trends. [PDF]
, 2020 Since 1998, 94 carsharing programs have been deployed in North America - 40 are operational and 52 are defunct. As of January 1, 2018, there were 18 active programs in Canada, 21 in the United States (U.S.), and one program in Mexico. In North America, carsharing membership totaled approximately 2,110,111 members sharing 23,376 vehicles.
Shaheen, Susan, PhD, Cohen, Adam
openaire +2 more sources
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Innovative trend analysis methods using multi-duration and variable length sub–series
Environmental Research CommunicationsClimate change is among the most critical challenges of our time and is clearly reflected in the rise of global mean temperatures. This study investigates global mean temperature trends for 1854–2023 using innovative trend analysis (ITA), frequency-based
Ismail Dabanli
doaj +1 more source
, 2010 Fundamental changes are taking place in the way we do astronomy. In twenty years time, it is likely that most astronomers will never go near a cutting-edge telescope, which will be much more efficiently operated in service mode.
Norris, Ray P.
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source