Results 91 to 100 of about 13,884,826 (327)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Promotion of leaf degradation by earthworms under laboratory conditions [PDF]
, 2006 Organic materials were applied to leaves from organic apple trees. Then, leaves were fed to earthworms in a laboratory culture. The objective was to select materials which promote leaf degradation by earthworms and consequently reduce the inoculum ...
de Jager, Anton +2 more
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Bio-Fertilizers via Co-Digestion: a Review [PDF]
, 2019 In diversifying the economies of most oil producing countries especially in regions with arable lands, Agriculture becomes the next choice aside mineral deposits.
Abdulkarim, Abdulwadud Yusuf +3 more
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Population-Level Dynamics and Community-Mediated Resistance to Antimicrobial Peptides
BiomoleculesAntimicrobial peptides (AMPs) are crucial components of innate immunity and promising leads for new anti-infective therapies, prized for their broad-spectrum activity and membrane-disruptive mechanisms. However, traditional models of antimicrobial action
Theresia Mekdessi +2 more
doaj +1 more source
Frontiers in Microbiology, 2016 This study evaluated the effect of increasing the proportion of bison relative to cattle inoculum on fermentation and microbial populations within an artificial rumen (Rusitec). The experiment was a completely randomized design with a factorial treatment
Daniela B Oss +6 more
doaj +1 more source
Bioremediation of contaminated soil : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Environmental Engineering at Massey University [PDF]
, 1997 The release of contaminants into the environment is inevitable. Contaminants are released through manufacture and use of products and as a result of treatment and disposal of wastes.
Wotherspoon, Robert Jason
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Microarray-based screening of differentially expressed genes of E. coli O157:H7 Sakai during preharvest survival on butterhead lettuce [PDF]
, 2016 Numerous outbreaks of Escherichia coli O157:H7 have been linked to the consumption of leafy vegetables. However, up to the present, little has been known about E.
Cottyn, Bart +6 more
core +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source