Results 11 to 20 of about 13,884,826 (327)

A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus. [PDF]

J Clin Microbiol, 2021
The cefazolin inoculum effect (CzIE) has been associated with therapeutic failures and mortality in invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections. A diagnostic test to detect the CzIE is not currently available.
Rincon S, Carvajal LP, Gomez-Villegas SI, Echeverri AM, Rios R, Dinh A, Pedroza C, Ordoñez KM, Nannini E, Sun Z, Fowler VG, Murray BE, Miller WR, Palzkill T, Diaz L, Arias CA, Reyes J.   +16 more
europepmc   +2 more sources

Targeting Dalbavancin Inoculum Effect: Adjunctive Single Dose of Daptomycin. [PDF]

Infect Dis Ther, 2023
Daptomycin (DAP) has proven to be a viable alternative amid vancomycin resistance; however, the use of DAP post vancomycin treatment has led to the development of DAP non-susceptible (DNS) strains. Dalbavancin (DAL), a novel single-dosed lipoglycopeptide, has shown enhanced activity against highly resistant Staphylococcus aureus strains.
Kebriaei R, Abdul-Mutakabbir JC, Stamper KC, Lev KL, Rybak MJ.   +4 more
europepmc   +6 more sources

PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo [PDF]

Frontiers in Pharmacology, 2022
The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of ...
Alexia Chauzy, Alexia Chauzy, Grace Akrong, Grace Akrong, Vincent Aranzana-Climent, Vincent Aranzana-Climent, Jérémy Moreau, Jérémy Moreau, Laure Prouvensier, Laure Prouvensier, Hélène Mirfendereski, Hélène Mirfendereski, Julien M Buyck, Julien M Buyck, William Couet, William Couet, William Couet, Sandrine Marchand, Sandrine Marchand, Sandrine Marchand   +19 more
doaj   +2 more sources

Clinical significance of cefazolin inoculum effect in serious MSSA infections: a systematic review. [PDF]

JAC Antimicrob Resist
Background The cefazolin inoculum effect (CzIE) is a phenomenon whereby some MSSA isolates demonstrate resistance to cefazolin when a high bacterial inoculum is used for susceptibility testing.
Lo CK, Sritharan A, Zhang J, Li N, Zhang C, Wang F, Loeb M, Bai AD.   +7 more
europepmc   +2 more sources

The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales [PDF]

mBio
Carbapenem-resistant Enterobacterales (CRE) are important pathogens that can develop resistance via multiple molecular mechanisms, including hydrolysis or reduced antibiotic influx.
Alexis Jaramillo Cartagena, Kyra L. Taylor, Leslie C. Lopez, Jennifer Su, Joshua T. Smith, Abigail L. Manson, Jonathan D. Chen, Virginia M. Pierce, Ashlee M. Earl, Roby P. Bhattacharyya   +9 more
doaj   +2 more sources

The Effect of Inoculum Size on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis

Microbiology Spectrum, 2023
Phenotypic drug susceptibility testing (DST) requires a standardized amount of inoculum to produce reproducible susceptibility results. The most critical step in the application of DST in Mycobacterium tuberculosis isolates is the preparation of the ...
Kubra Yildirim, Cemilenur Atas, Ece Simsek, Ahmet Yilmaz Coban   +3 more
doaj   +2 more sources

Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children. [PDF]

Antimicrob Agents Chemother, 2020
Select methicillin-susceptible Staphylococcus aureus (MSSA) strains may produce β-lactamases with affinity for first-generation cephalosporins (1GCs). In the setting of a high inoculum, these β-lactamases may promote the cleavage of 1GCs, a phenomenon ...
McNeil JC, Sommer LM, Boyle M, Hogan P, Vallejo JG, Hultén KG, Flores AR, Kaplan SL, Fritz S.   +8 more
europepmc   +2 more sources

Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae [PDF]

Annals of Clinical Microbiology and Antimicrobials, 2023
Objective To evaluate effect of inoculum size of extended-spectrum β-Lactamase (ESBL)-producing-, AmpC-producing-, and KPC-producing Escherichia coli and Klebsiella pneumoniae on the in vitro antibacterial effects of imipenem/relebactam (IMR) and ...
Xueting Wang, Luying Xiong, Yuan Wang, Kai Yang, Tingting Xiao, Xiaohui Chi, Tao Chen, Yanzi Zhou, Ping Lu, Dilimulati Dilinuer, Pin Shen, Yunbo Chen, Yonghong Xiao   +12 more
doaj   +2 more sources

Novel Insights into the Classification of Staphylococcal β-Lactamases in Relation to the Cefazolin Inoculum Effect. [PDF]

Antimicrob Agents Chemother, 2020
Cefazolin has become a prominent therapy for methicillin-susceptible Staphylococcus aureus (MSSA) infections. However, an important concern is the cefazolin inoculum effect (CzIE), a phenomenon mediated by staphylococcal β-lactamases.
Carvajal LP, Rincon S, Echeverri AM, Porras J, Rios R, Ordoñez KM, Seas C, Gomez-Villegas SI, Diaz L, Arias CA, Reyes J.   +10 more
europepmc   +2 more sources

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics [PDF]

Microbiology Spectrum
The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking.
Daniella M. Hernandez, Melissa Marzouk, Madeline Cole, Marla C. Fortoul, Saipranavi Reddy Kethireddy, Rehan Contractor, Habibul Islam, Trent Moulder, Ariane R. Kalifa, Estefania Marin Meneses, Maximiliano Barbosa Mendoza, Ruth Thomas, Saad Masud, Sheena Pubien, Patricia Milanes, Gabriela Diaz-Tang, Allison J. Lopatkin, Robert P. Smith   +17 more
doaj   +2 more sources