Results 21 to 30 of about 13,884,826 (327)

β-Lactam Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus Infective Endocarditis.

JAMA Netw Open
Key Points Question Is the clinical outcome of methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis associated with some underappreciated phenotypic characteristics of the bacterial strains and the β-lactam used?
Jean B, Crolle M, Pollani C, Le Guilloux A, Martin-Blondel G, Tattevin P, Le Bot A, Luque Paz D, Guérin F, Cattoir V, Armand-Lefevre L, Gueye S, Lescure FX, Duval X, Massip C, Delobel P.   +15 more
europepmc   +2 more sources

The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies [PDF]

Infectious Diseases and Therapy
Methicillin-susceptible Staphylococcus aureus (MSSA) remains a major cause of morbidity and mortality worldwide, particularly owing to its role in complicated infections including bloodstream infections, osteomyelitis, and infective endocarditis. In 2017,
Prakhar Srivastava, Elizabeth Singleton, Taylor Morrisette, Andrew David Berti, Remi Lorenzo Ventresca, Emily Brassell, Lyuba Benin, Razieh Kebriaei   +7 more
doaj   +2 more sources

The Cefazolin Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible Staphylococcus aureus Bacteremia. [PDF]

Open Forum Infect Dis, 2018
Background Recent studies have favored the use of cefazolin over nafcillin for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia.
Miller WR, Seas C, Carvajal LP, Diaz L, Echeverri AM, Ferro C, Rios R, Porras P, Luna C, Gotuzzo E, Munita JM, Nannini E, Carcamo C, Reyes J, Arias CA.   +14 more
europepmc   +2 more sources

The Cefazolin Inoculum Effect and the Presence of type A blaZ Gene according to agr Genotype in Methicillin-Susceptible Staphylococcus aureus Bacteremia. [PDF]

Infect Chemother, 2019
Background Recent data suggests the inoculum effect of methicillin-susceptible Staphylococcus aureus (MSSA) against beta-lactam antibiotics and their association with functionality or genotypic variation of agr locus.
Lee SO, Lee S, Park S, Lee JE, Lee SH.
europepmc   +2 more sources

A rapid culture system uninfluenced by an inoculum effect increases reliability and convenience for drug susceptibility testing of Mycobacterium tuberculosis. [PDF]

Sci Rep, 2018
The Disc Agarose Channel (DAC) system utilizes microfluidics and imaging technologies and is fully automated and capable of tracking single cell growth to produce Mycobacterium tuberculosis (MTB) drug susceptibility testing (DST) results within 3~7 days.
Jung YG, Kim H, Lee S, Kim S, Jo E, Kim EG, Choi J, Kim HJ, Yoo J, Lee HJ, Kim H, Jung H, Ryoo S, Kwon S.   +13 more
europepmc   +2 more sources

Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis. [PDF]

Antimicrob Agents Chemother, 2018
We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE).
Miller WR, Singh KV, Arias CA, Murray BE.   +3 more
europepmc   +2 more sources

Prevalence of a Cefazolin Inoculum Effect Associated with blaZ Gene Types among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago. [PDF]

Antimicrob Agents Chemother, 2018
The efficacy of cefazolin with high-inoculum methicillin-susceptible Staphylococcus aureus (MSSA) infections remains in question due to therapeutic failure inferred as being due to an inoculum effect (InE). This study investigated the local prevalence of
Wang SK, Gilchrist A, Loukitcheva A, Plotkin BJ, Sigar IM, Gross AE, O'Donnell JN, Pettit N, Buros A, O'Driscoll T, Rhodes NJ, Bethel C, Segreti J, Charnot-Katsikas A, Singh K, Scheetz MH.   +15 more
europepmc   +2 more sources

Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with β-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions. [PDF]

Antimicrob Agents Chemother, 2018
Enterococcus faecium isolates that harbor LiaFSR substitutions but are phenotypically susceptible to daptomycin (DAP) by current breakpoints are problematic, since predisposition to resistance may lead to therapeutic failure.
Kebriaei R, Rice SA, Singh KV, Stamper KC, Dinh AQ, Rios R, Diaz L, Murray BE, Munita JM, Tran TT, Arias CA, Rybak MJ.   +11 more
europepmc   +2 more sources

The pharmacodynamic inoculum effect from the perspective of bacterial population modeling [PDF]

bioRxiv, 2019
AbstractThe quantitative determination of the effects of antimicrobials is essential for our understanding of pharmacodynamics and for their rational clinical application. Common pharmacodynamic measures of antimicrobial efficacy, such as the MIC and the pharmacodynamic function, fail to capture the observed dependence of efficacy on the bacterial ...
Desiree Y. Baeder, Roland R. Regoes
openaire   +2 more sources

Respons Peningkatan Nutrisi Pelepah Sawit Fermentasi yang Diinokulasi dengan Inokulum Berbeda [PDF]

Ziraa'ah: Majalah Ilmiah Pertanian, 2013
The purpose of this study was to determine the effect of different types of inoculum for protein content ( PK ) and crude fiber fermentation of palm frond. Research using randomized design (RAL) 4 treatments and 5 replications .
Danang Biyatmoko
doaj   +4 more sources