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Inosine 5'-monophosphate dehydrogenase (IMPDH; EC 1.1.1.205) isolated from Escherichia coli B3 cells was strongly inhibited by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate (2-FVIMP). Inhibition of IMPDH appears to be irreversible with k(inact) and K(i) values of 0.0269 s(-1) and 1.11 microM, respectively.
Vasu, Nair, Ramesh C, Kamboj
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Theraspberry locus encodesDrosophila inosine monophosphate dehydrogenase
Molecular and General Genetics MGG, 1995Investigation of an enhancer-trap line exhibiting testis-specific beta-galactosidase expression led to the isolation of the Drosophila gene encoding inosine monophosphate dehydrogenase (IMPD), the rate-limiting enzyme in guanine nucleotide synthesis, which has been implicated in cell cycle control and malignant transformation.
R, Slee, M, Bownes
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