Results 11 to 20 of about 25,315 (221)
Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases.
PLoS ONE, 2019 There is variability as to how archaea catalyze the final step of de novo purine biosynthesis to form inosine 5'-monophosphate (IMP) from 5-formamidoimidazole-4-carboxamide ribonucleotide (FAICAR).
Caroline A Hunter +3 more
doaj +4 more sources
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis. [PDF]
FASEB J, 2021 Abstract Inosine monophosphate (IMP) is the intracellular precursor for both adenosine monophosphate and guanosine monophosphate and thus plays a central role in intracellular purine metabolism. IMP can also serve as an extracellular signaling molecule, and can regulate diverse processes such as taste sensation ...
Lovászi M +5 more
europepmc +3 more sources
Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase
Nature CommunicationsAllosteric regulation of inosine 5′-monophosphate dehydrogenase (IMPDH), an essential enzyme of purine metabolism, contributes to the homeostasis of adenine and guanine nucleotides. However, the precise molecular mechanism of IMPDH regulation in bacteria
Ondřej Bulvas +8 more
doaj +4 more sources
A mutant of phosphomannomutase1 retains full enzymatic activity, but is not activated by IMP: Possible implications for the disease PMM2-CDG. [PDF]
PLoS ONE, 2017 The most frequent disorder of glycosylation, PMM2-CDG, is caused by a deficiency of phosphomannomutase activity. In humans two paralogous enzymes exist, both of them require mannose 1,6-bis-phosphate or glucose 1,6-bis-phosphate as activators, but only ...
Valentina Citro +5 more
doaj +1 more source
Nature Communications, 2020 Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and
Akira Imamura +12 more
doaj +1 more source
Succinate and inosine coordinate innate immune response to bacterial infection.
PLoS Pathogens, 2022 Macrophages restrict bacterial infection partly by stimulating phagocytosis and partly by stimulating release of cytokines and complement components.
Ming Jiang +6 more
doaj +1 more source
Inosine monophosphate dehydrogenase and myeloid cell maturation [PDF]
Blood, 1987 In previous studies of purine ribonucleotide metabolism in the human myeloid leukemia cell line HL-60, we observed that there is a down- regulation of guanine ribonucleotide biosynthesis from the central intermediate, inosine monophosphate (IMP) and a depletion of intracellular guanosine triphosphate (GTP) and guanosine diphosphate (GDP) pools that ...
R D, Knight +5 more
openaire +3 more sources
Insights Into Gut Barrier Dysfunction and Metabolic Alterations in Mycophenolate-Induced Enteropathy. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Mycophenolic acid (MPA) is a widely used immunosuppressant whose use is often limited by gastrointestinal toxicity. Gut bacterial hydrolysis of liver‐derived MPA glucuronides increases local exposure to MPA, potentially impairing epithelial barrier function and cellular metabolism.
Brossier C +6 more
europepmc +2 more sources
Immunosuppressants and risk of Parkinson disease [PDF]
, 2018 We performed a population-based case-control study of United States Medicare beneficiaries age 60-90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use ...
Camacho-Soto, Alejandra +5 more
core +2 more sources