Frontiers in Nutrition, 2022 The study investigated the changes of nucleotides, succinic acid, and free amino acids amounts in yolk and the causes leading to the changes after pickling to uncover the fundamental umami component of preserved egg yolk.
Binghong Gao +8 more
doaj +1 more source
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]
, 2018 Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona +6 more
core +3 more sources
Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]
, 1985 The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina, +8 more
core +2 more sources
Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]
, 2017 A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea +2 more
core +1 more source
Production of Guanosine-5′-Monophosphate and Inosine-5′-Monophosphate by Fermentation [PDF]
Applied Microbiology, 1966 A biotin-requiring coryneform bacterium which produces glutamic acid was mutated to adenine dependency. The adenine-requiring strain, which excreted insoine-5′-monophosphate (IMP), was further mutated to xanthine dependency. As expected, IMP was also excreted by this mutant.
A L, Demain +4 more
openaire +2 more sources
EFFECT OF PARTIAL REPLACEMENT OF MONOSODIUM GLUTAMATE BY 5΄-INOSINE MONOPHOSPHATE ON THE FERTILITY OF MALE RATS [PDF]
Arab Universities Journal of Agricultural Sciences, 2014 This work aimed to study the effect of partial replacement of monosodium glutamate (MSG) by 5΄ inosine monophosphate (5΄-IMP) on the fertility of male rats after oral administration for 90 days.
Abeer M.N.H. Eldakak +2 more
doaj +1 more source
Components of the Nucleotide Salvage Pathway Increase Frog Virus 3 (FV3) Replication
Viruses, 2023 Viruses are obligate intracellular parasites that alter host metabolic machinery to obtain energy and macromolecules that are pivotal for replication.
Samantha R. Logan +3 more
doaj +1 more source
Inosine Monophosphate Dehydrogenase Pharmacogenetics in Hematopoietic Cell Transplantation Patients. [PDF]
Biol Blood Marrow Transplant, 2018 We evaluated inosine monophosphate dehydrogenase (IMPDH) 1 and IMPDH2 pharmacogenetics in 247 recipient-donor pairs after nonmyeloablative hematopoietic cell transplant (HCT). Patients were conditioned with total body irradiation + fludarabine and received grafts from related or unrelated donors (10% HLA mismatch), with postgraft immunosuppression of ...
McCune JS +5 more
europepmc +4 more sources
6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]
, 2006 Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
A. Teml +52 more
core +1 more source
Brazilian Journal of Food Technology, 2018 This study proposed a method to determine the sum of the concentrations of inosine 5’-monophosphate (IMP) and guanosine 5’-monophosphate (GMP) in final and intermediate products through a combination of UV spectroscopy and multivariate calibration ...
Regina Andreia Ferrari Pereira +2 more
doaj +1 more source