Results 61 to 70 of about 9,913 (182)

Insights from electromechanical simulations to assess omecamtiv mecarbil efficacy in heart failure

The Journal of Physiology, EarlyView.
Abstract figure legend Impact of Omecamtiv Mecarbil (OM) on in‐silico models of heart failure. A mathematical electromechanical model of human ventricular tissue is used to simulate the effects of OM in heart failure with reduced ejection fraction (HFrEF).
Maria Teresa Mora, Ilse van Herck, Cécile Daversin‐Catty, Henrik Finsberg, Jordi Llopis‐Lorente, Javier Saiz, Hermenegild Arevalo, Samuel Wall, Beatriz Trenor   +8 more
wiley   +1 more source

A retrospective study on laboratory‐confirmed acute Chinese medicine poisoning involving aconite in Hong Kong from 2008 to 2020

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 1, February 2026.
Abstract Background Territory‐wide epidemiological studies of acute Chinese medicine poisoning involving aconite after 2010 are lacking. Objectives To characterise the latest trends, presumed causes, clinical presentations, healthcare utilisation and patient outcomes of such poisoning cases in Hong Kong.
Rex Pui Kin Lam, Shuk Ching Ting, Tsz Kit Chow, Ka Kit Chua, Ping Yui Ku, Chi Keung Chan, Man Li Tse, Eric Ho Yin Lau, Jin Zhao, Timothy Hudson Rainer   +9 more
wiley   +1 more source

Cerebral effects of commonly used vasopressor-inotropes: a study in newborn piglets.

PLoS ONE, 2013
BackgroundDespite widespread use in sick infants, it is still debated whether vasopressor-inotropes have direct cerebral effects that might affect neurological outcome.
Gitte H Hahn, Simon Hyttel-Sorensen, Sandra M Petersen, Ole Pryds, Gorm Greisen   +4 more
doaj   +1 more source

Immune Checkpoint Inhibitor‐Associated Myocarditis With Myositis/Myasthenia Gravis Overlap Syndrome: Two Case Reports Highlighting Early Onset, Diagnostic Uncertainty, and Management Considerations

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Custom illustration created by the author in collaboration with the Mayo Clinic Digital Media Department. ABSTRACT Immune checkpoint‐inhibitors (ICIs) have revolutionized and significantly improved cancer care through remarkable efficacy, but significant adverse effects have been observed.
Artur Schneider, Nikita Jhawar, Deepica Reddy, Razvan Chirila   +3 more
wiley   +1 more source

Assessing the Utility of Targeted Neonatal Echocardiography for Congenital Heart Disease Detection: Retrospective Cohort Analysis

Journal of Clinical Ultrasound, Volume 54, Issue 1, Page 81-87, January 2026.
Targeted neonatal echocardiography showed good agreement with cardiology‐performed studies in detecting significant congenital heart disease. Most missed lesions were minor, highlighting both the value of TNE in neonatal care and the need for continued training to optimize diagnostic accuracy.
Eyad Bitar, Aimann Surak, Rula Agarushi, Dawn Pepper, Matt Hicks, Abbas Hyderi, Lisa K. Hornberger, Luke Eckersley, Kumar Kumaran   +8 more
wiley   +1 more source

Retrospective Case Series of Fulminant Metabolic Crisis in GSDIA: Persistent Lactic Acidosis Despite Correction of Hypoglycemia May Reflect Secondary Mitochondrial Dysfunction

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Although several advances in glycogen storage disorder (GSD) management have been made over the years, there is still increased morbidity and mortality in these patients, particularly among those with GSD type I (GSDI). Here, we describe a case series of five patients with GSDIa who presented with severe lactic acidosis and passed away without
Herodes Guzman, Nicole Stewart, Lauren Mitteer, Victoria Sanders, Rebecca Ganetzky, Diva D. De Leon   +5 more
wiley   +1 more source

A physiologic Comparison of Continuous Neurally Adjusted Ventilation (NeuroPAP) Versus Neurally‐Adjusted Ventilatory Assist (NAVA) in Infants With Respiratory Failure

Pediatric Pulmonology, Volume 61, Issue 1, January 2026.
ABSTRACT Objectives And Hypothesis Tonic diaphragmatic activity is common during non‐invasive ventilation (NIV), suggesting efforts to increase end‐expiratory lung volume. We assessed the feasibility and physiological impact of NeuroPAP, a novel NIV mode continuously adjusting the delivered positive pressure proportionally to diaphragm electric ...
Virginie Plante, Laurence Tabone, Jennifer Beck, Christer Sinderby, Sylvain Morneau, Gregory A. Lodygensky, Michael Sauthier, Florent Baudin, Guillaume Emeriaud   +8 more
wiley   +1 more source

Percutaneous Reperfusion Therapies vs. Anticoagulation in Patients With Acute Intermediate‐High‐Risk Pulmonary Embolism: The PRETHA Randomized Clinical Trial

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT The optimal treatment strategy for patients with acute intermediate–high‐risk pulmonary embolism (PE) remains uncertain. This randomized clinical trial (PRETHA) aimed to evaluate the efficacy and safety of percutaneous reperfusion therapies—trans‐catheter thrombectomy and trans‐catheter thrombolysis—compared with standard anticoagulation ...
Taida Ivanauskienė, Andrius Berūkštis, Greta Burneikaitė, Aurelija Daubaraitė, Kastė Ivanauskaitė, Mindaugas Matačiūnas, Giedrius Navickas, Rasa Kūgienė, Marcin Kurzyna, Sigita Glaveckaitė   +9 more
wiley   +1 more source

Inotropes and cardiorenal syndrome in acute heart failure – A retrospective comparative analysis

Revista Portuguesa de Cardiologia, 2017
Introduction: Cardiorenal syndrome (CRS) is common in acute heart failure (AHF), and is associated with dire prognosis. Levosimendan, a positive inotrope that also has diuretic effects, may improve patients’ renal profile.
Marta Madeira, Francisca Caetano, Inês Almeida, Andreia Fernandes, Liliana Reis, Marco Costa, Lino Gonçalves   +6 more
doaj   +1 more source

Evaluation of Hemodynamic Changes in Normovolemic Hypotensive Dogs Treated With Fluids Alone or in Combination With Ephedrine or Dobutamine

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Crystalloid fluids alone did not improve normovolemic hypotension in anesthetized dogs. Ephedrine or dobutamine reversed hemodynamic changes, but combining either with fluids offered no added benefit. Notably, dobutamine with fluids may have adverse effects. Larger studies are needed to assess differences between treatments.
Pardis Varzandeh, Bahman Mosallanejad, Hadi Imani Rastabi, Mohammad Razi Jalali, Seyed Reza Fatemi Tabatabaei   +4 more
wiley   +1 more source