Results 21 to 30 of about 447 (129)

A MassQL‐Based Framework for Rule‐Guided MS/MS Class‐Level Retrieval and Analog Discovery of Cannabinoids

Rapid Communications in Mass Spectrometry, Volume 40, Issue 16, 30 August 2026.
ABSTRACT Rationale Cannabinoids comprise a chemically diverse group of meroterpenoids whose extensive isomerism, variable side‐chain length, and frequent oxidative or rearranged derivatives lead to strongly overlapping yet characteristic MS/MS fragmentation patterns. In untargeted LC–MS/MS datasets, this combination of structural diversity and spectral
Julia Maia Galvão de Queiroz, Fernanda Oliveira Chagas, Valdir Florêncio Veiga‐Júnior, Monica Costa Padilha, Ricardo M. Borges   +4 more
wiley   +1 more source

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite, Lucas H. S. Ocarino, Gabriel C. Veríssimo, Philipe O. Fernandes, Dara Fernanda Pereira, Fernanda Kelly M. e Oliveira, Alberto Marbán‐González, José L. Medina‐Franco, Mateus Sá M. Serafim, Thales Kronenberger, Vinícius G. Maltarollo   +10 more
wiley   +1 more source

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source

Análise da gestão da cadeia de valor da inovação em uma empresa do setor siderúrgico [PDF]

Gestão & Produção, 2014
A gestão da inovação é um processo estruturado que possibilita que uma organização perceba novas maneiras de criar valor e de antever demandas tecnológicas e mercadológicas.
Angelo Varandas Junior, Mario Sergio Salerno, Paulo Augusto Cauchick Miguel   +2 more
doaj   +3 more sources

Limitations and Strengths of the SH‐SY5Y Neuroblastoma Cell Line as a Model of β‐Amyloid Neurotoxicity: Lessons From a Systematic Review and Meta‐Analysis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
The SH‐SY5Y human neuroblastoma cell line has been widely used to model β‐amyloid (Aβ) neurotoxicity linked to Alzheimer's disease (AD). Motivated by the high diversity of protocols for neuronal differentiation of SH‐SY5Y cells, we performed a systematic review, aiming to identify the variables of SH‐SY5Y cell culture and treatment protocols that most ...
Nathalia R. Pinheiro, Clarissa F. D. Carneiro, Giulia S. Cancelliero, Giovanna O. Nogueira, Glaucia M. Almeida, Nathalia Fernandes, Ana Paula Wasilewska‐Sampaio, Samantha M. Martins, Antonio Felix, Olavo B. Amaral, Adriano Sebollela   +10 more
wiley   +1 more source

Inovação através do design: princípios sistêmicos do pensamento projetual

Design e Tecnologia, 2011
Este artigo trata da utilização do Design como um instrumento, um gerador de diferencial competitivo, a serviço da inovação. Em um primeiro momento são revisados conceitos gerais de inovação e específicos a partir da visão do Design. A seguir, é abordada
Renata Gastal Porto
doaj   +1 more source

Processability and Crosslink Density: Role of Peptizers in Natural Rubber and Chlorobutyl Rubber

Journal of Applied Polymer Science, Volume 143, Issue 22, June 10, 2026.
This work evaluates how chemical and physical peptizers affect mastication, vulcanization behavior, and network formation in natural rubber and chlorobutyl rubber. Size‐exclusion chromatography, rheometry, DSC, and swelling analyses demonstrate improved processability but reduced crosslink density with peptizer addition.
Amanda F. Baruel, Sérgio L. G. Petroni, Sandra A. C. de Mello, Jorge C. N. Dutra, Silvana N. Cassu   +4 more
wiley   +1 more source

THE REGISTRY OF GEOGRAPHICAL INDICATION AND THE LEVEL OF INNOVATION

Revista INGI, 2019
O registro de uma Indicação Geográfica (IG) no Instituto Nacional de Propriedade Industrial (INPI) é um fator muito importante para o detentor do título, porque proporciona a abertura de mercado, principalmente para a comercialização e/ou importação, e ...
Renata Bittencourt, Valdir Silva Conceição, Paulo S. Figueiredo   +2 more
doaj  

Fontes de informação para inovação: estudo de casos em Santa Catarina

Navus: Revista de Gestão e Tecnologia, 2019
Aborda a investigação das fontes de informação para inovação utilizadas pelos programas e mecanismo para o desenvolvimento de startups em Santa Cataria no segmento de tecnologia e inovação.
Priscila Machado Borges Sena, Ursula Blattmann, Gabriela Gonçalves Silveira Fiates   +2 more
doaj   +1 more source

Distinct Neuronal Activation in the Paraventricular Nucleus of the Hypothalamus Accompanies Baroreflex Impairment and Elevated Cardiac Sympathetic Tone in Salt‐Loaded Rats

European Journal of Neuroscience, Volume 63, Issue 10, May 2026.
This study investigated an animal model of short‐term high‐salt exposure (2% NaCl) for 7 days and its effects on baroreflex function, cardiac autonomic balance, and the pattern of paraventricular nucleus of the hypothalamus (PVH) neuronal activation during a baroreflex loading. High salt intake leads to an increase in blood pressure (BP) and heart rate
Angelo Bernak de Oliveira, Pedro Sousa Soares, Paula Magalhães Gomes, Vagner Roberto Antunes   +3 more
wiley   +1 more source