Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Dynamic evolution analysis of the factors driving the growth of energy-related CO2 emissions in China: An input-output analysis. [PDF]
Ma Y, Song Z, Li S, Jiang T.
europepmc +1 more source
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Using input-output analysis to model the impact of pandemic mitigation and suppression measures on the workforce. [PDF]
Santos J.
europepmc +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Supply versus use designs of environmental extensions in input-output analysis: Conceptual and empirical implications for the case of energy. [PDF]
Wieland H +6 more
europepmc +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
OPORTUNIDADES PERDIDAS EN MAGALLANES LOST OPPORTUNITIES IN MAGALLANES
Muchos investigadores destacan la importancia de las relaciones entre sectores con el fin de sugerir medidas relativas al crecimiento económico (estudios sobre eslabonamientos o linkages), pero pocos, conjugan dicha información con los efectos que tiene ...
SERGIO SOZA-AMIGO +1 more
doaj
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Energy input-output analysis of paddy fields under different irrigation modes and nitrogen fertilizer managements. [PDF]
Zhang Y +9 more
europepmc +1 more source

