Results 41 to 50 of about 10,586,533 (310)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Input/output selection for planar tensegrity models [PDF]

Proceedings of the 40th IEEE Conference on Decision and Control (Cat. No.01CH37228), 2002
A systematic method of selecting sensors and actuators is produced, efficiently selecting inputs and outputs that guarantee a desired level of performance in the H8-norm sense. The method employs an efficiently computable necessary and sufficient existence condition, using an effective search strategy.
de Jager, Bram, Skelton, R.E.
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Recovery ot the Input-Output Analysis in the Czech Republic [PDF]

Statistika: Statistics and Economy Journal, 2019
The input-output analysis has a long tradition in the former Czechoslovakia starting in the 1960s. These models were originally used for central planning and price re-construction during socialism.
Jaroslav Sixta
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Evaluating the robustness of the ARIO model for a local disaster: 2021 flooding in Germany

Environmental Research: Infrastructure and Sustainability
Given the interconnectedness of modern economies and the widespread adoption of just-in-time production methods, even minor disruptions caused by natural disasters can lead to substantial indirect economic impact.
Samuel Juhel, Adrien Delahais, Vincent Viguié   +2 more
doaj   +1 more source

ASSESSMENT OF SHADOW ECONOMY IN MOLDOVA USING THE INPUT-OUTPUT MODEL IN 2014 [PDF]

Economy and Sociology, 2016
The shadow economy is the bane of modern society. Paradoxically, as the community is poorer, the level of the shadow economy is higher, which in turn leads to lower allocations in the budget, and as a consequence reduces social benefits, reducing the ...
Valentina GANCIUCOV, Tatiana GUTIUM, Alexandru CEBAN   +2 more
doaj  

Preparing a dynamic model for water filtering process in Mosul city [PDF]

المجلة العراقية للعلوم الاحصائية, 2013
In this research the scientific dynamic process is studied concering water filtering in Mosul city through employing the input and output variables represented by some tests which were performed on raw water before the filtering process, to be treated ...
doaj   +1 more source

An input-output model of interactive systems [PDF]

Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, 1986
Interactive user interfaces depend critically on underlying computing system facilities for input and output. However, most computing systems still have input-output facilities designed for batch processing. These facilities are not adequate for interfaces that rely on graphical output, interactive input, or software constructed with modern ...
openaire   +1 more source