Results 41 to 50 of about 5,279,152 (305)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The role of small- and medium-sized enterprises in the Dutch economy: an analysis using an extended supply and use table

Journal of Economic Structures, 2019
Firm size is increasingly acknowledged as an important factor for (macro-)economic policy. It is known that the overall importance of small- and medium-sized enterprises (SMEs) is different relative to large multinationals in terms of their impact on ...
Stephen Chong, Rutger Hoekstra, Oscar Lemmers, Ilke Van Beveren, Marcel Van Den Berg, Ron Van Der Wal, Piet Verbiest   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dataset of China's non-competitive constant price input-output tables for 2007 and 2012

Data in Brief, 2019
The China's Input-Output tables for 2007 and 2012 which were published by the China National Bureau of Statistics are competitive current price input-output tables.
Miao Yu, Xintong Zhao, Yuning Gao
doaj   +1 more source

The Feasibility of creating jobs in Renewable energy using input-output approach: a case study of solar and wind energy [PDF]

Pizhūhishnāmah-i Iqtiṣād-i Inirzhī-i Īrān, 2016
The feasibility Study of creating jobs in Renewable Energy using input- output approach renewable energy employment is important employment of this system because of new nature is more than fossil fuels.
Zeinolabedin Sadeghi, Fatemeh Shamsodin pour, Hamid Reza Mirzae   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Structural Analysis of European Union Economy [PDF]

Revista Română de Statistică, 2016
Based on the input-output analysis, the paper characterizes the structure of European economy in 2010 and 2011, on six main economic sectors. The sectoral structures of backward and forward linkages, and their absolute effects starting from the final ...
Liliana DUGULEANĂ, Constantin DUGULEANĂ, Steliana BUSUIOCEANU   +2 more
doaj  

Misallocation of Resources and Economic Growth in Iran: An Input-Output Approach [PDF]

فصلنامه پژوهش‌های اقتصادی ایران, 2017
The Iranian economy suffers from low economic growth despite having access to enormous reserves of natural resources. The role of investment rate as the driving force of economic growth has been the focus of much debate among macroeconomists. This raises
Esfandiyar Jahangard
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source