Results 71 to 80 of about 2,590,076 (294)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

An input-output analysis: linkages vs leakages [PDF]

Resorting to input-output analysis, intersectoral linkages are investigated. For such assessment, the distinction between imported and domestically supplied inputs, which has been disregarded so far in empirical analysis, is crucial.
António Rua, Hugo J. Reis
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Recent evolution of wine exports in a turbulence period: a multiregional input-output analysis. [PDF]

Agric Food Econ, 2023
Carrasco I, Castillo-Valero JS, Carchano M, Córcoles C.   +3 more
europepmc   +1 more source

Technology-intensive industries - Input-output analysis [PDF]

, 2010
By the analyses included in this paper I tried to quantify â using the input-output method â the amplitude of upstream and downstream linkages between manufacturing industries, structured by technological groups, for Romania and other six EU member ...
Olteanu, Dan
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Estructuras productivas y desarrollo: el caso de la economía chilena || Productive Structures and Development: The Case of the Chilean Economy

Revista de Métodos Cuantitativos para la Economía y la Empresa, 2018
Esta investigación se inicia con las siguientes interrogantes: ¿existe consistencia entre la identificación de desarrollo y la estructura económica que se posee?; ¿existen parecidos entre economías identificadas con distintos niveles de desarrollo?; y ...
Soza-Amigo, Sergio, Aroca, Patricio
doaj  

Regional Economic Growth Disparities in Ukraine: Input-Output Analysis Approach

Scientific Annals of Economics and Business, 2017
Regional inequalities in economic growth had been observed within many countries and regions. This research emphasizes convergence/divergence technique for Ukrainian regions.
Hryhorkiv Vasyl, Verstiak Andrii, Verstiak Oksana, Hryhorkiv Mariia   +3 more
doaj   +1 more source

Methodology of the input-output analysis [PDF]

In the near future consequences of the anthropogenic climate change will be more and more perceptible all over the world. But the regional distribution will differ substantially even between regions within the same country.
Kowalewski, Julia
core