Results 41 to 50 of about 320,487 (342)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Dasein and inter-esse, or how event is design
I provide an insight into Being’s self-realization, emphasizing inter-esse as event as a twofold designal quality in resoluteness and a propensity toward the other.
Anton Heinrich Rennesland
doaj
Two New Pahlavi Inscriptions from Fars Province, Iran [PDF]
First edition of two previously unknown Middle Persian inscriptions from the region of Fars in ...
Asadi, Ali, Cereti, Carlo G.
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Contrary to Levinas, the event of hospitality does not take place in the face of the other, but rather, in the work of art. Art should therefore not be viewed as provoking pleasure, but rather, as an event of hospitality of radical alterity possessing ...
Dror Pimentel
doaj
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
This essay introduces Félix Guattari’s semiotics, paying particular attention to the role of “inscription,” which he will associate with distribution of and upon the social body.
Timothy Deane-Freeman
doaj
Marco Vitale ist wissenschaftlicher Mitarbeiter in Alter Geschichte (Epigraphie, Numismatik) in Basel und Zürich. Er wurde 2010 promoviert mit einer Untersuchung zur Verwaltung der hellenistischen und römischen Asia Minor (Eparchie und Koinon).
Vitale, Marco
core +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source

