Results 41 to 50 of about 2,888 (268)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Affected Persons in Laboratory Exposures to Human Pathogens and Toxins in Canada, 2016–2024: A Sector‐Specific Analysis

open access: yesAmerican Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Exposures to human pathogens and toxins in licensed facilities in Canada have been monitored by a federal surveillance system since 2015, yet the affected persons (APs) in these incidents remain uncharacterized. This study comprehensively describes APs, highlighting sector‐specific patterns and trends over time.
Emily F. Tran   +4 more
wiley   +1 more source

Three‐dimensional digital analysis of musteloid masticatory muscle architecture

open access: yesThe Anatomical Record, EarlyView.
Musteloids span an enormous breadth of dietary modes within a single superfamily. In this study, we utilize digital dissection techniques to reconstruct the internal 3D anatomy of muscles within the musteloid feeding apparatus, and explore how dietary specializations might alter the size, orientation, and curvature of fascicles therein.
Cassidy E. Davis   +6 more
wiley   +1 more source

Bite force estimates and morphological correlations of jaw muscles in parrots

open access: yesThe Anatomical Record, EarlyView.
Abstract Parrots (Order: Psittaciformes) are renowned for their high bite force (BF) and morphological correlates thereof, including a highly mobile skull and two unique mandibular adductor muscles—m. pseudomasseter and m. ethmomandibularis, with the former being hypothesized to increase force output.
Ana Carolina L. Faillace   +3 more
wiley   +1 more source

A Date Palm Worker Dies After Being Stung by Bees [PDF]

open access: yes
A date palm tree worker died after being stung by numerous bees while working in an organic date orchard. The victim and a co-worker were spraying the dates with high-pressure water when the incident occurred.

core   +1 more source

Redescription of the cranial morphology of Amphisbaena braestrupi and Amphisbaena laurenti (Squamata: Amphisbaenidae) from the Pleistocene of Brazil using x‐ray computed tomography

open access: yesThe Anatomical Record, EarlyView.
Abstract Amphisbaenians (Squamata: Amphisbaenidae) are fossorial reptiles with highly specialized cranial morphology, yet their fossil record is frequently limited by fragmentary preservation. This study provides a detailed osteological redescription of the skulls of Amphisbaena braestrupi and Amphisbaena laurenti from the Pleistocene of Lagoa Santa ...
Carolina L. Paiva   +2 more
wiley   +1 more source

Redescription of †Eobrasilia coutoi (Metatheria: Polydolopimorphia), a unique sclerocarpophagous metatherian from the Palaeogene of South America: Systematic affinities, and paleoecological and evolutionary implications

open access: yesThe Anatomical Record, EarlyView.
Abstract The ‘Palaeogene strata’ of the Itaboraí Basin (upper Paleocene‐lower Eocene), Southeastern Brazil, has preserved 29 genera and almost 50 species of metatherians (about 65% of its mammalian diversity). Among them, Eobrasilia coutoi Simpson, 1947 is the most enigmatic due to its quite fragmentary nature.
Leonardo M. Carneiro   +10 more
wiley   +1 more source

Bioerosion traces in bones reveal an increase in ethological diversity in the insect exploitation of carcasses in the late Triassic

open access: yesThe Anatomical Record, EarlyView.
Abstract This study presents the first detailed description of bioerosion traces produced by insects in bones from the Santa Cruz Sequence (early Carnian, Santa Maria Supersequence, Brazil). An array of traces is reported, consisting of notches, a tube, trails of grooves attributed to the ichnotaxon Osteocallis mandibulus and ornamented depressions ...
Lucca S. Cunha   +2 more
wiley   +1 more source

Duck Orbivirus and Egg Production: A Newly Identified Duck Orbivirus Is the Etiological Agent of Egg Production Decline in Chinese Breeder Ducks

open access: yesAnimal Research and One Health, EarlyView.
Field samples from breeder duck farms with egg‐production decline were subjected to viral detection, genome sequencing, and virus isolation. Experimental infection demonstrated that duck orbivirus (DORV) causes a significant and persistent reduction in egg production in breeder ducks.
Bing Li   +18 more
wiley   +1 more source

Avaliação do uso de repelentes contra picada de mosquitos em militares na Bacia Amazônica Evaluation of the use of repellent against mosquito bite by military personnel in the Amazon Basin

open access: yesAnais Brasileiros de Dermatologia, 2010
FUNDAMENTOS: No Brasil, doenças provocadas por picadas de insetos são frequentes, o que torna extremamente importante a execução de medidas profiláticas de forma adequada, sobretudo, em áreas endêmicas como a Amazônia, que recebe um grande contingente de
Jonas Ribas, Ana Maria Carreño
doaj   +1 more source

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