Results 21 to 30 of about 46,761 (209)

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

Angewandte Chemie International Edition, EarlyView.
A biosynthesis route for the polymer precursor tulipalin A starting from isoprenyl acetate is proposed. The alkane monooxygenase AlkB catalyzes the chemoselective terminal hydroxylation of isoprenyl acetate. Rational enzyme engineering further increased the activity of the membrane enzyme.
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi, Lars Christian Lund, Jesper Hallas, Martin Thomsen Ernst, Anton Pottegård   +4 more
wiley   +1 more source

Chemical Composition and Synergistic Antimicrobial Effects of Essential Oils From Four Commonly Used Satureja Species in Combination With Two Conventional Antibiotics

Chemistry &Biodiversity, EarlyView.
The chemical composition and the in vitro synergistic antimicrobial effects of four Satureja essential oils were investigated. Essential oils from Satureja montana and S. hortensis displayed strong antimicrobial effects, whereas S. calamintha and S. alpina exhibited relatively weaker antimicrobial activity.
Imane Abbad, Bouchra Soulaimani, Marcello Iriti, Mustapha Barakate   +3 more
wiley   +1 more source

Chemical Components of the Dried Latex of Euphorbia resinifera Berg and Its Medicinal Features

Chemistry &Biodiversity, EarlyView.
ABSTRACT A great deal of research has been carried out on the latex of Euphorbia resinifera Berg, which is an important source of several compounds of therapeutic and medicinal interest. Extraction, synthesis, and hemi synthesis pathways continue to reveal the existence of other new products with anticancer, antioxidant, antidiuretic, and antimalarial ...
Doaa Hammad, El‐Mahdi Ourhzif, Salha Hamri, Hafid Abderrafia, Mostafa Khouili, Maria Dolors Pujol   +5 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

New Terpenoids from Viguiera dentata: In Silico Pesticide‐Likeness Properties, Acetylcholinesterase Inhibition, Molecular Docking, and Evaluation against Spodoptera frugiperda

Chemistry &Biodiversity, EarlyView.
The chemical analysis of aerial parts of the melliferous Viguiera dentata led to the isolation of 20 substances, including the new cycloartanes 24‐epi‐argentatin C, 7β‐hydroxy‐24‐epi‐argentatin C, 7β‐hydroxy‐argentatin B. In‐combo results indicated that specific argentatins and ent‐kaurenoic acids have the potential to control Spodoptera frugiperda ...
Amira Arciniegas, Olivia Pérez‐Valera, Simón Hernández‐Ortega, Antonio Nieto‐Camacho, Israel Valencia, Joel Daniel Castañeda‐Espinoza, Rodolfo Figueroa‐Brito, José Luis Villaseñor, Guillermo Delgado   +8 more
wiley   +1 more source

Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential

ChemBioEng Reviews, EarlyView.
This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona, Kaveh Shahbaz, Saeid Baroutian   +2 more
wiley   +1 more source

A Thermostable Bacterial Metallohydrolase that Degrades Organophosphate Plasticizers

ChemBioChem, EarlyView.
This bacterial enzyme, cyclase‐phosphotriesterase (C‐PTE) from Ruegeria pomeroyi DSS‐3, shows significant potential for breaking down organophosphate pollutants. Beyond its capability to hydrolyze specific plasticizers such as triphenyl phosphate and tris(2‐chloropropyl) phosphate, C‐PTE's crystal structure reveals a binuclear zinc active site, and it ...
Dawei Ji, Rebecca L. Frkic, Javad Delyami, Joachim S. Larsen, Matthew A. Spence, Colin J. Jackson   +5 more
wiley   +1 more source

Electrocatalytic CN Coupling: Advances in Urea Synthesis and Opportunities for Alternative Products

ChemSusChem, EarlyView.
This review explores electrocatalytic urea synthesis via carbon–nitrogen (CN) coupling from CO2 and nitrogen species, specifically nitrate, nitrite, nitric oxide, and nitrogen gas. It discusses recent discoveries in catalyst design, reaction pathways, and detection methods. Future outlooks on industrial applications, alternative CN coupling products,
Parker Ballard‐Kyle, Isabel Hsieh, Huiyuan Zhu   +2 more
wiley   +1 more source

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

ChemSusChem, EarlyView.
Chlorine is essential for the production of plastics and pharmaceuticals but poses significant safety and environmental risks. Herein, processes are presented that substitute chlorine or reduce its demand. Where indispensable, trichloride‐ and bichloride‐based ionic liquids could enhance safety and streamline the integration of renewable energy ...
Johannes Schwan, Merlin Kleoff, Gesa H. Dreyhsig, Patrick Voßnacker, Traute Fiedler, Marian Rosental, Sebastian Riedel   +6 more
wiley   +1 more source