Results 91 to 100 of about 193,449 (246)
Scientific ReportsKnee osteoarthritis (KOA) has a high prevalence among the elderly, severely affecting their quality of life and imposing a considerable burden on social health insurance.
Fangxing Wang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Journal of Experimental OrthopaedicsPurpose Unicompartmental knee arthroplasty (UKAs) are available in the market as fixed‐ and mobile‐bearing (FB and MB) and can be characterised by a different set of design parameters in terms of geometries, materials and surgical approaches, with ...
Thomas Luyckx +5 more
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Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Deconstructing the steps of pull-type PEG tube insertion
VideoGIEVideo 1Deconstructed steps of the pull-type PEG insertion technique.
Ravishankar Asokkumar +5 more
openaire +3 more sources
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
INTERVIUL RADIOFONIC CU TEMATICĂ POLITICĂ: ABORDĂRI TEORETICE ŞI PRACTICI OPERAȚIONALE
Studia Universitatis Moldaviae: Stiinte Sociale, 2017 Noile realităţi politice conturate după declararea independenţei Republicii Moldova au generat schimbări importante şi în profilul genurilor radiofonice. Abordarea teoretică a interviului radiofonic cu tematică politică, dar şi exerciţiul practic creează
Mariana MARCU
doaj
Investigation of the mechanical properties of inserting-type support frames
Scientific ReportsIn this paper, a widely used disc-buckle support frame is taken as the object, and parallel positive and negative bending tests are carried out on the connection nodes of the disc-buckle support frame. The failure mode, stress distribution law and bending resistance of the connection nodes of the disc-buckle support frame are systematically studied ...
Guangjun Cheng +3 more
openaire +3 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source