Results 91 to 100 of about 4,057 (206)

Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis

eLife, 2020
The outer-membrane of Gram-negative bacteria is critical for surface adhesion, pathogenicity, antibiotic resistance and survival. The major constituent – hydrophobic β-barrel Outer-Membrane Proteins (OMPs) – are first secreted across the inner-membrane ...
Sara Alvira, Daniel W Watkins, Luca A Troman, William J Allen, James S Lorriman, Gianluca Degliesposti, Eli J Cohen, Morgan Beeby, Bertram Daum, Vicki AM Gold, J Mark Skehel, Ian Collinson   +11 more
doaj   +1 more source

Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases

ChemBioChem, Volume 26, Issue 9, May 5, 2025.
Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley   +1 more source

A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways [PDF]

, 2017
The majority of multi-spanning membrane proteins are co-translationally inserted into the bilayer by the Sec pathway. An important subset of membrane proteins have globular, cofactor-containing extracytoplasmic domains requiring the dual action of the co-
Andersson, Bachmann, Bageshwar, Baniulis, Bartolomé, Berks, Bernhardt, Blaudeck, Bogdanov, Bogsch, Brokx, Brondijk, Caldelari, Casadaban, Cole, Collinson, Cooley, Cristóbal, Cymer, Dalbey, De Buck, Elofsson, Gennaris, Goder, Guzman, Hatzixanthis, Hedin, Heijne, Hessa, Hessa, Hopkins, Inouye, Ize, Ize, Jack, Jack, James, Jormakka, Keller, Kern, Koch, Kreutzenbeck, Krogh, Kudva, Lehr, Li, Liu, Lowry, Ma, Monteferrante, Musser, Nilsson, Ojemalm, Palmer, Puigbò, Rose, Sachelaru, Samuelson, Schneider, Scotti, Shanmugham, Stanley, Stanley, Summers, Tsirigos, Tsirigos, Tullman-Ercek, Ulbrandt, Urbanus, Virkki, von Heijne, Wahlberg, Wallin, Wexler, White, White, Zhu   +76 more
core   +3 more sources

Reconstitution of bacterial autotransporter assembly using purified components

eLife, 2014
Autotransporters are a superfamily of bacterial virulence factors consisting of an N-terminal extracellular (‘passenger’) domain and a C-terminal β barrel (‘β’) domain that resides in the outer membrane (OM).
Giselle Roman-Hernandez, Janine H Peterson, Harris D Bernstein   +2 more
doaj   +1 more source

Physiological Importance of Molybdate Transporter Family 1 in Feeding the Molybdenum Cofactor Biosynthesis Pathway in Arabidopsis thaliana

Molecules, 2022
Molybdate uptake and molybdenum cofactor (Moco) biosynthesis were investigated in detail in the last few decades. The present study critically reviews our present knowledge about eukaryotic molybdate transporters (MOT) and focuses on the model plant ...
Rieke Minner-Meinen, Jan-Niklas Weber, Sarah Kistner, Paul Meyfarth, Merve Saudhof, Lena van den Hout, Jutta Schulze, Ralf-Rainer Mendel, Robert Hänsch, David Kaufholdt   +9 more
doaj   +1 more source

ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts [PDF]

, 2016
Multicomponent biological systems perform a wide variety of functions and are crucially important for a broad range of critical health and disease states.
A Basters, A Kriz, AB Rode, AJ Jakobi, B Geering, B Weiss, BM Olivera, C Bieniossek, C Bieniossek, C Romier, C Schaffitzel, CP Chou, CV Robinson, D Busso, D Sari, D Schelshorn, DG Gibson, DJ Pitera, DN Gopaul, F Guo, F Leinert, G Bartani, G Gosset, G Kellenberger, H Alper, H Ye, HO Smith, J Komar, J Quan, J Torella, JA Chemler, JH Park, K Ballmer-Hofer, KB Mullis, LF Estrozi, LR Jarboe, LS Vijayachandran, M Folcher, M Gellert, M Haffke, M Haffke, M Meselson, MCY Chang, ML Diebold, ML Gefter, MZ Li, N Zheng, NR Cozzarelli, O Loeffelholz Von, PE Nisson, PJA Cock, R Patnaik, R Vincentelli, RJ Schulze, S Ausländer, S Cunna, S Linn, S Trowitzsch, S Trowitzsch, SC Almo, SE Luria, SJ Berríos-Rivera, SK Lee, SY Lee, T Maniatis, TC Terwilliger, VC Bode, W Abdulrahman, W Weber, WW Metcalf, Y Nie, Y Zhang   +71 more
core   +3 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, Volume 599, Issue 10, Page 1373-1385, May 2025.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao, Ben‐Chi Zhao, Hui‐Lin Li, Ying Liu, Bei Wang, An‐Qi Li, Tian‐Shu Zeng, Hannah Xiaoyan Hui, Jia Sun, Domagoj Cikes, Nele Gheldof, Jorg Hager, Jian‐Xun Mi, D. Ross Laybutt, Yin‐Yue Deng, Yan‐Chuan Shi, G. Gregory Neely, Qiao‐Ping Wang   +17 more
wiley   +1 more source

Each protomer of a dimeric YidC functions as a single membrane insertase [PDF]

Scientific Reports, 2018
Abstract The membrane insertase YidC catalyzes the entrance of newly synthesized proteins into the lipid bilayer. As an integral membrane protein itself, YidC can be found as a monomer, a dimer or also as a member of the holotranslocase SecYEGDF-YajC-YidC.
Spann, Dirk, Pross, Eva, Chen, Yuanyuan, Dalbey, Ross E., Kuhn, Andreas   +4 more
openaire   +2 more sources

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase [PDF]

Nature, 2014
Hundreds of tail-anchored proteins, including soluble N-ethylmaleimide-sensitive factor attachment receptors (SNAREs) involved in vesicle fusion, are inserted post-translationally into the endoplasmic reticulum membrane by a dedicated protein-targeting pathway.
Fei, Wang, Charlene, Chan, Nicholas R, Weir, Vladimir, Denic   +3 more
openaire   +2 more sources