Results 181 to 190 of about 4,057 (206)

The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase [PDF]

open access: yesNature, 2021
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the antimicrobial resistance crisis1-3. Gram-negative bacteria are protected by an additional outer membrane, rendering proteins on the cell surface attractive drug targets4,5.
H. Kaur   +11 more
semanticscholar   +6 more sources
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Membrane insertases at a glance

Journal of Cell Science, 2023
ABSTRACT Protein translocases, such as the bacterial SecY complex, the Sec61 complex of the endoplasmic reticulum (ER) and the mitochondrial translocases, facilitate the transport of proteins across membranes. In addition, they catalyze the insertion of integral membrane proteins into the lipid bilayer.
Büsra Kizmaz, Johannes M. Herrmann
openaire   +2 more sources

SND3 is the membrane insertase within a fungal multipass translocon

open access: yesbioRxiv
Abstract During the biogenesis of most eukaryotic integral membrane proteins (IMPs), transmembrane domains are inserted into the endoplasmic reticulum membrane by a dedicated insertase or the SEC61 translocon. The SRP-independent (SND) pathway is the least understood route into the membrane, despite catering for a broad range of IMP types ...
Tzu-Jing Yang   +4 more
semanticscholar   +2 more sources

Transient local secondary structure in the intrinsically disordered C‐term of the Albino3 insertase

The FASEB Journal, 2022
Albino3 (Alb3) is an integral membrane protein fundamental to the targeting and insertion of light‐harvesting complex (LHC) proteins into the thylakoid membrane.
P. Okoto   +7 more
semanticscholar   +1 more source

Inner Membrane Translocases and Insertases

2019
The inner membrane of Gram-negative bacteria is a ~6 nm thick phospholipid bilayer. It forms a semi-permeable barrier between the cytoplasm and periplasm allowing only regulated export and import of ions, sugar polymers, DNA and proteins. Inner membrane proteins, embedded via hydrophobic transmembrane α-helices, play an essential role in this regulated
Jozefien, De Geyter   +3 more
openaire   +2 more sources

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