Deciphering the Interdomain Coupling in a Gram-Negative Bacterial Membrane Insertase. [PDF]
J Phys Chem BYidC is a membrane protein that plays an important role in inserting newly generated proteins into lipid membranes. The Sec-dependent complex is responsible for inserting proteins into the lipid bilayer, and this process is facilitated by YidC in ...
Polasa A, Badiee SA, Moradi M.
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Chloroplast Ribosomes Interact With the Insertase Alb3 in the Thylakoid Membrane [PDF]
Frontiers in Plant Science, 2021 Members of the Oxa1/YidC/Alb3 protein family are involved in the insertion, folding, and assembly of membrane proteins in mitochondria, bacteria, and chloroplasts.
Bernd Ackermann +7 more
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The Final Step in Molybdenum Cofactor Biosynthesis—A Historical View [PDF]
MoleculesMolybdenum (Mo) is an essential micronutrient across all kingdoms of life, where it functions as a key component of the active centers of molybdenum-dependent enzymes.
Ralf R. Mendel, Kevin D. Oliphant
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The Role of Protein–Lipid Interactions in Priming the Bacterial Translocon [PDF]
MembranesProtein–lipid interactions demonstrate important regulatory roles in the function of membrane proteins. Nevertheless, due to the semi-liquid nature and heterogeneity of biological membranes, and dissecting the details of such interactions at high ...
Matt Sinclair, Emad Tajkhorshid
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Scientific Reports, 2021 The membrane insertase YidC inserts newly synthesized proteins by its hydrophobic slide consisting of the two transmembrane (TM) segments TM3 and TM5. Mutations in this part of the protein affect the insertion of the client proteins.
Anja Steudle +5 more
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Structure of the ER membrane complex, a transmembrane-domain insertase
Nature, 2020 The endoplasmic reticulum (ER) membrane complex (EMC) cooperates with the Sec61 translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass integral membrane proteins into the ER membrane, and it is also responsible for ...
Lin Bai +4 more
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The EMC acts as a chaperone for membrane proteins [PDF]
Nature CommunicationsStructure formation of membrane proteins is error-prone and thus requires chaperones that oversee this essential process in cell biology. The ER membrane protein complex (EMC) is well-defined as a transmembrane domain (TMD) insertase.
Carolin J. Klose +7 more
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The conserved outer mitochondrial membrane protein Mtch regulates mitophagy during Drosophila intestinal development. [PDF]
PLoS BiologyThe clearance of mitochondria by autophagy (mitophagy) is important for cell health. Mutations in genes that are required for mitophagy, including Vps13D, PINK1, and Parkin, are associated with movement disorders, but gaps exist in our understanding of ...
Lucas J Restrepo +3 more
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Structure-based insights into the mechanism of [4Fe-4S]-dependent sulfur insertase LarE. [PDF]
Protein Sci, 2023 Several essential cellular metabolites, such as enzyme cofactors, contain sulfur atoms and their biosynthesis requires specific thiolation enzymes.
Zecchin P +6 more
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The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER
Cell Reports, 2023 Summary: Tail-anchored (TA) proteins contain a single C-terminal transmembrane domain (TMD) that is captured by the cytosolic Get3 in yeast (TRC40 in humans).
Paul Heo +4 more
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