POTRA domains of the TamA insertase interact with the outer membrane and modulate membrane properties. [PDF]
Proc Natl Acad Sci U S ASignificance TamA is the catalytic core of the translocation and assembly module, a transenvelope complex facilitating the assembly of specific outer-membrane proteins (OMPs) in gram-negative bacteria.
Mellouk A +9 more
europepmc +2 more sources
Exome sequencing in retinal dystrophy patients reveals a novel candidate gene ER membrane protein complex subunit 3 [PDF]
Heliyon, 2023 Inherited retinal dystrophies (IRDs) are a heterogeneous group of visual disorders caused by different pathogenic mutations in genes and regulatory sequences. The endoplasmic reticulum (ER) membrane protein complex (EMC) subunit 3 (EMC3) is the core unit
Yan-Ping Li +6 more
doaj +2 more sources
The ER membrane protein complex is a transmembrane domain insertase [PDF]
Science, 2017 A new way into the ER Membrane-embedded proteins are highly diverse in topology, physical characteristics, and location. This diversity necessitates multiple pathways for their effective membrane insertion. Guna et al.
Alina Guna +3 more
semanticscholar +4 more sources
Biomolecules, 2021 Members of the DUF34 (domain of unknown function 34) family, also known as the NIF3 protein superfamily, are ubiquitous across superkingdoms. Proteins of this family have been widely annotated as “GTP cyclohydrolase I type 2” through electronic ...
Colbie J. Reed +2 more
doaj +2 more sources
The multifaceted mitochondrial OXA insertase.
Trends in Cell Biology, 2023 Most mitochondrial proteins are synthesized in the cytosol and transported into mitochondria by protein translocases. Yet, mitochondria contain their own genome and gene expression system, which generates proteins that are inserted in the inner membrane by the oxidase assembly (OXA) insertase.
Bettina Homberg +2 more
semanticscholar +5 more sources
Features of membrane protein sequence direct post-translational insertion [PDF]
Nature CommunicationsThe proper folding of multispanning membrane proteins (MPs) hinges on the accurate insertion of their transmembrane helices (TMs) into the membrane. Predominantly, TMs are inserted during protein translation, via a conserved mechanism centered around the
Ilya A. Kalinin +6 more
doaj +2 more sources
A structural model of the active ribosome-bound membrane protein insertase YidC
eLife, 2014 The integration of most membrane proteins into the cytoplasmic membrane of bacteria occurs co-translationally. The universally conserved YidC protein mediates this process either individually as a membrane protein insertase, or in concert with the SecY ...
Stephan Wickles +9 more
doaj +6 more sources
The insertase YidC chaperones the polytopic membrane protein MelB inserting and folding simultaneously from both termini. [PDF]
Structure, 2023 Blaimschein N +8 more
europepmc +2 more sources
The OXA2a Insertase of Arabidopsis Is Required for Cytochrome c Maturation1
Plant Physiology, 2020 Arabidopsis mitochondria require a specific inner membrane insertase for efficient biogenesis of c-type cytochromes. In yeast (Saccharomyces cerevisiae) and human (Homo sapiens) mitochondria, Oxidase assembly protein1 (Oxa1) is the general insertase for ...
Renuka Kolli +5 more
semanticscholar +4 more sources
YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production. [PDF]
J Biol ChemZhao Z +14 more
europepmc +2 more sources