Loss of ALBINO3b Insertase Results in Truncated Light-Harvesting Antenna in Diatoms1[OPEN] [PDF]
Plant Physiology, 2019 Diatom ALB3b is required for insertion of Fx-Chl-binding proteins in thylakoid membranes and has a novel conserved domain implying that its interaction partners differ from those in plants/green algae.
M. Nymark +8 more
semanticscholar +6 more sources
STIC2 selectively binds ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins [PDF]
The EMBO JournalChloroplast-encoded multi-span thylakoid membrane proteins are crucial for photosynthetic complexes, yet the coordination of their biogenesis remains poorly understood.
Dominique S Stolle +16 more
doaj +2 more sources
Structure of Precursor-Bound NifEN: A Nitrogenase FeMo Cofactor Maturase/Insertase [PDF]
Science, 2011 NifEN plays an essential role in the biosynthesis of the nitrogenase iron-molybdenum (FeMo) cofactor (M cluster). It is an α_2β_2 tetramer that is homologous to the catalytic molybdenum-iron (MoFe) protein (NifDK) component of nitrogenase.
Hu, Yilin +4 more
core +5 more sources
Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase
Cell Reports, 2022 Summary: The evolution of zinc (Zn) as a protein cofactor altered the functional landscape of biology, but dependency on Zn also created an Achilles’ heel, necessitating adaptive mechanisms to ensure Zn availability to proteins.
Miriam Pasquini +8 more
doaj +1 more source
Off-target structural insights: ArnA and AcrB in bacterial membrane-protein cryo-EM analysis. [PDF]
Acta Crystallogr D Struct BiolThis study highlights that cryo‐EM can reveal structural information beyond the intended target, and that overexpression of membrane proteins involved in quality control may lead to the co‐purification of proteins such as ArnA and AcrB.Membrane‐protein quality control in Escherichia coli involves coordinated actions of the AAA+ protease FtsH, the ...
Caliseki M +4 more
europepmc +3 more sources
Lipid scrambling is a general feature of protein insertases. [PDF]
Proc Natl Acad Sci U S A, 2023 Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER and membranes derived from it to grow. Lipid equilibration is facilitated by integral membrane proteins called “scramblases.” These proteins feature a hydrophilic groove ...
Li D +4 more
europepmc +4 more sources
Frontiers in Microbiology, 2021 Integral and membrane-anchored proteins are pivotal to survival and virulence of the dental pathogen, Streptococcus mutans. The bacterial chaperone/insertase, YidC, contributes to membrane protein translocation.
Surabhi Mishra, L. Jeannine Brady
doaj +1 more source
Strong Environmental and Genome-Wide Population Differentiation Underpins Adaptation and High Genomic Vulnerability in the Dominant Australian Kelp (<i>Ecklonia radiata</i>). [PDF]
Ecol EvolThe dominant Australian kelp, Ecklonia radiata, was genotyped from 10 locations spanning a 2000 km latitudinal gradient along the east coast of Australia using ddRAD sequencing. Strong genetic differentiation was found between mainland Australia and Tasmania, while adaptive SNP candidates identified local adaptation at the species' range edges with low
Minne AJP +6 more
europepmc +2 more sources
Insertases scramble lipids: Molecular simulations of MTCH2
Structure, 2023 AbstractScramblases play a pivotal role in facilitating bidirectional lipid transport across cell membranes, thereby influencing lipid metabolism, membrane homeostasis, and cellular signaling. MTCH2, a mitochondrial outer membrane protein insertase, has a membrane-spanning hydrophilic groove resembling those that form the lipid transit pathway in known
Ladislav Bartoš +2 more
openaire +4 more sources