Results 91 to 100 of about 852,097 (307)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
More than one insertion loss, throughout the day, for the same outdoor noise barrier [PDF]
, 2011 ISO 10847:1997 establishes a method for determining the insertion loss of noise barriers, assuming the existence of only one insertion loss for the same outdoor noise barrier.
Conceição, E. Z. E., Rosão, Vitor
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Design and realisation of a MZI type polymer based high speed EO-modulator [PDF]
, 1996 We designed a 20 GHz Mach Zehnder interferometric EO-modulator based on a new developed polyesterimide. Measurements show a V/sub /spl pi// of 7.5 V, an insertion loss of 11 dB and an extinction ratio exceeding 20 dB for an interaction length of 2 ...
Chan, Y.P. +9 more
core +2 more sources
Performance of T-shape barriers with top surface covered with absorptive quadratic residue diffusers [PDF]
, 2008 A previous paper [Applied Acoustics 66 (2005) 709–730] has shown that adding a quadratic residue diffuser (QRD) to the top of a T-shape barrier can provide better barrier performance than an equivalent purely absorptive barrier.
Lam, YW, Monazzam, M
core +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Applied Sciences, 2019 To address the performance bottleneck in metal-based interconnects, hybrid optical network-on-chip (HONoC) has emerged as a new alternative. However, as the size of the HONoC grows, insertion loss and crosstalk noise increase, leading to excessive laser ...
Jun Yeong Jang +3 more
doaj +1 more source
A 10-20 GHz 6-Bit High-Accuracy Digital Step Attenuator with Low Insertion Loss in 0.15 µm GaAs p-HEMT Technology. [PDF]
Micromachines (Basel), 2023 He D +6 more
europepmc +1 more source