Results 61 to 70 of about 852,097 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Modelling the Acoustic Properties of Baffles Made of Porous and Fibrous Materials

open access: yesArchives of Acoustics
The research described in the article addresses the problem of measurement, prediction and practical use of the acoustic properties of materials determined in an impedance tube.
Krzysztof KOSAŁA
doaj   +1 more source

Possibilities of Evaluating the Effectiveness of Noise Barriers in Slovakia

open access: yesApplied Sciences, 2021
This paper presents environmental acute problems from increasing noise levels caused by automobile and rail transport. Noise barriers are considered to be an effective element in reducing noise in densely populated urban areas. However, do these barriers
Alžbeta Pultznerová   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Fabrication and coupling to planar high-Q silica disk microcavities [PDF]

open access: yes, 2003
Using standard lithographic techniques, we demonstrate fabrication of silica disk microcavities, which exhibit whispering-gallery-type modes having quality factors (Q) in excess of 1 million.
Armani, D. K.   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Non-Destructive Sensor for Glucose Solution Concentration Detection Using Electromagnetic Technology

open access: yesMicromachines
In this paper, a sensor using a complementary split ring resonator (CSRR) is proposed for non-destructive testing of blood glucose. By depicting the complementary split ring structure on the ground, the electromagnetic field strength between the split ...
Shasha Yang   +5 more
doaj   +1 more source

A Psychoacoustic Investigation on the Effect of External Shading Devices on Building Facades

open access: yesApplied Sciences, 2016
Due to energetic and natural lighting factors, building facades often present external shading devices, but the acoustic properties of such devices have not yet been well studied.
Nicolò Zuccherini Martello   +4 more
doaj   +1 more source

A wideband CPW ring power combiner with low insertion loss and high port isolation [PDF]

open access: yes, 2012
In this paper we present a coplanar waveguide (CPW)-based ring power combiner that exhibits less than 0.8 dB insertion loss, better than 15 dB port match and higher than 22 dB isolation loss over the frequency range from 50 GHz to 100 GHz.
Cumming, D.R.S.   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Home - About - Disclaimer - Privacy