Results 141 to 150 of about 401,827 (385)

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Deterioration of sleep and mental health in individuals with insomnia during South Africa’s COVID-19 lockdown

South African Journal of Science
Sleep and mental health difficulties have been observed in response to COVID-19 pandemic-induced lockdowns, but few studies have described the impact of lockdown on individuals with self-reported insomnia.
Alison Bentley, Laura C. Roden, Jonathan P. Davy, Stella Iacovides, F. Xavier Gómez-Olivé, Karine Scheuermaier, Raphaella Lewis, Gosia Lipinska, Johanna Roche, Candice J. Christie, Swantje Wells, Dale E. Rae   +11 more
doaj   +1 more source

Evidence Based Complementary Intervention for Insomnia [PDF]

, 2002
Increasing scientific evidence point to a non-pharmacological complementary treatment for insomnia: white noise. Its presentation has been shown to induce sleep in human neonates and adults, probably by reducing the signal-to-noise ratio of ambient ...
Bracha, Adam S., Bracha, Dr. Stefan, Lopez, Dr. Hassen H.   +2 more
core  

Feasibility and Acceptability of Brief Behavioral Treatment for Insomnia After Eating Disorder Treatment: The TIRED Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The purpose of this pilot trial was to evaluate the novel use of Brief Behavioral Treatment for Insomnia (BBTI) for people with residual insomnia disorder following eating disorder (ED) treatment. Methods Participants (N = 6) completed a multiple‐baseline design study of BBTI.
Kara A. Christensen Pacella, Angeline R. Bottera, Kelsie T. Forbush, Jaelin Isquith, Kyle De Young   +4 more
wiley   +1 more source

Insomnia and Mild Cognitive Impairment

Gerontology and Geriatric Medicine, 2018
Insomnia is a common problem in older people, especially in patients with mild cognitive impairment (MCI) whose circadian rhythm is often compromised.
R. C. Hamdy MD, A. Kinser PhD, K. Dickerson FNP, T. Kendall-Wilson RN, A. Depelteau PhD, R. Copeland MD, K. Whalen BA   +6 more
doaj   +1 more source

The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3 pathogenic variants

Epilepsia Open, EarlyView.
Abstract We report two cases of dual genetic diagnoses involving Lafora disease (LD) and co‐occurring neurodevelopmental disorders caused by pathogenic variants in TRIO and SHANK3, respectively. LD is an ultra‐rare, autosomal recessive, severe form of progressive myoclonus epilepsy affecting previously healthy children or adolescents. In both patients,
Lorenzo Muccioli, Francesca Bisulli, Raffaella Minardi, Maria Lucia Valentino, Micaela De Simone, Rodrigo Almeida Paroni, Edward Cesnik, Elisa Fallica, Luigi Bonan, Eleonora Pizzi, DEFEAT‐LD Study Group, Cosimo Altomare, Massimo Carella, Cinzia Costa, Giuseppe Damante, Lidia Di Vito, Giuseppe d’Orsi, Nicola Gambacorta, Paola Imbrici, Valentina Imperatore, Antonella Liantonio, Laura Licchetta, Raffaele Lodi, Paola Mantuano, Orazio Palumbo, Elena Pasini, Paolo Prontera, Luca Vignatelli, Gaetano Cantalupo, Laura Licchetta   +29 more
wiley   +1 more source

HUBUNGAN TINGKAT STRES DENGAN INSOMNIA PADA SISWA-SISWI SEKOLAH MENENGAH PERTAMA DI FATIH BILINGUAL BOARDING SCHOOL BANDA ACEH [PDF]

, 2013
ABSTRAKStres merupakan salah satu faktor yang dapat menyebabkan insomnia, dan insomnia merupakan salah satu akibat yang dapat ditimbulkan ketika seseorang mengalami stress yang berlebihan.Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat ...
Aulia Rizky
core  

The Wet Pack in the Treatment of Insomnia and Mental Disorders [PDF]

, 1914
Henry Rayner
openalex   +1 more source

The Effect of Anxiety and Depression on Sleep Quality of Individuals With High Risk for Insomnia: A Population-Based Study

Frontiers in Neurology, 2019
Introduction: One of the most common sleep disorders, insomnia is a significant public health concern. Several psychiatric disorders, such as anxiety disorders and depression, have shown strong relationships with insomnia. However, the clinical impact of
C. Oh, H. Y. Kim, Han Kyu Na, K. Cho, M. Chu   +4 more
semanticscholar   +1 more source

Nonseizure symptoms and broader seizure impacts in patients with Dravet syndrome and Lennox–Gastaut syndrome in clinical practice settings: Results from a multinational survey

Epilepsia Open, EarlyView.
Abstract Objective To assess the burden of Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS), including managing seizure and nonseizure symptoms, on patients and caregivers. Methods Data were drawn from the Adelphi Real World DS and LGS Disease Specific Programme™, a cross‐sectional survey in Asia (China, Japan), Europe (France, Germany, Italy ...
Drishti Shah, Vicente Villanueva, Dennis Dlugos, Arturo Benitez, Yasmin Taylor, Stevie Olsen, Hannah Connolly, Sophie Lai, J. Scott Andrews   +8 more
wiley   +1 more source