Results 11 to 20 of about 34,475 (222)

A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes

American Journal of Hematology, Volume 98, Issue 2, Page 272-281, February 2023., 2023
Abstract Patients with relapsed/refractory (R/R) higher‐risk myelodysplastic syndromes (MDS) have a dismal median overall survival (OS) after failing hypomethylating agent (HMA) treatment. There is no standard of care for patients after HMA therapy failure; hence, there is a critical need for effective therapeutic strategies.
Amer M. Zeidan, Uma Borate, Daniel A. Pollyea, Andrew M. Brunner, Fernando Roncolato, Jacqueline S. Garcia, Robin Filshie, Olatoyosi Odenike, Anne Marie Watson, Ravitharan Krishnadasan, Ashish Bajel, Kiran Naqvi, Jiuhong Zha, Wei‐Han Cheng, Ying Zhou, David Hoffman, Jason G. Harb, Jalaja Potluri, Guillermo Garcia‐Manero   +18 more
wiley   +1 more source

Multivariate analyses of molecular genetic associations between childhood psychopathology and adult mood disorders and related traits

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 192, Issue 1-2, Page 3-12, January-March 2023., 2023
Abstract Ubiquitous associations have been detected between different types of childhood psychopathology and polygenic risk scores based on adult psychiatric disorders and related adult outcomes, indicating that genetic factors partly explain the association between childhood psychopathology and adult outcomes. However, these analyses in general do not
Wonuola A. Akingbuwa, Anke R. Hammerschlag, Andrea G. Allegrini, Hannah Sallis, Ralf Kuja‐Halkola, Kaili Rimfeld, Paul Lichtenstein, Sebastian Lundstrom, Marcus R. Munafò, Robert Plomin, Michel G. Nivard, Meike Bartels, Christel M. Middeldorp   +12 more
wiley   +1 more source

Insomnia in patients with acute heart failure: from the KCHF registry

ESC Heart Failure, 2022
Aims Insomnia is a known risk factor for heart failure (HF) and a predictor of cardiac events in HF patients, but the clinical significance of insomnia in patients with acute HF (AHF) is not adequately evaluated.
Yuta Seko, Erika Yamamoto, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Masayuki Shiba, Yusuke Yoshikawa, Yugo Yamashita, Takeshi Kitai, Ryoji Taniguchi, Moritake Iguchi, Kazuya Nagao, Takafumi Kawai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Koichiro Kuwahara, Takeshi Kimura, for the KCHF Study Investigators   +27 more
doaj   +1 more source

Mental health symptoms and sleep quality of asymptomatic/mild SARS‐CoV‐2 infected individuals during the Omicron wave of the COVID‐19 pandemic in Shanghai China

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Objective To investigate mental health symptoms (anxiety, depression, and sleep status) and their associated factors among people infected with the SARS‐CoV‐2 omicron variant during the quarantine period in Shanghai. Methods To investigate the mental health symptoms among participants with SARS‐CoV‐2 omicron infection, an anonymous online ...
Zhenghua Hou, Yingzi Huang, Shaolei Ma, Hui Feng, Cuiping Fu, Han Li, Yuexing Yuan, Yonggui Yuan   +7 more
wiley   +1 more source

Quantitative electroencephalographic analysis of delirium tremens development following alcohol‐withdrawal seizure based on a small number of male cases

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Considering the complications related to alcohol withdrawal syndrome (AWS) such as seizure, delirium tremens and cardiac arrhythmia, it is important to identify the risk of delirium tremens (DT) following AWS and enhance preventive strategies. We observed the characteristics of quantitative electroencephalography in patients with AWS, specifically who ...
Jee‐Eun Yoon, Heejung Mo, Dong Wook Kim, Hee‐Jin Im   +3 more
wiley   +1 more source

A Wearable EEG System for Closed-Loop Neuromodulation of High-Frequency Sleep-Related Oscillations [PDF]

, 2022
In healthy sleepers, cortical alpha oscillations are present during the transition from wakefulness to sleep, and dissipate at sleep onset. For individuals with insomnia, alpha power is elevated during the wake-sleep transition and can persist throughout the night.
arxiv   +1 more source

Permutation Entropy as a Conceptual Model to Analyse Brain Activity in Sleep [PDF]

, 2023
Sleep stage classification is a widely discussed topic, due to its importance in the diagnosis of sleep disorders, e.g. insomnia. Analysis of the brain activity during sleep is necessary to gain further insight into the processing that occurs in our brains. We want to use permutation entropy as a model for this analysis.
arxiv   +1 more source

Insomnia Mental Health Issues Pandemic Covid-19

Psycho Idea, 2022
Insomnia is one of the major sleep disorders that faced by people which lead to mental health issues. Inability to get enough amount of sleep that can causing difficulty to function during the daytime.
Samsiah Jayos, Lau Ngie Hing, Aima Aimaduddin Bin Bollhasan   +2 more
doaj   +1 more source

Association between insomnia and subclinical atherosclerosis among Chinese steelworkers: a cross-sectional survey

Archives of Public Health, 2022
Background Insomnia is a common prevalent sleep disorder. Difficulty maintaining sleep or poor in quality in insomnia caused by disrupted or misaligned circadian rhythms may play an important role in the development of atherosclerosis.
Lihua Wang, Shengkui Zhang, Miao Yu, Juxiang Yuan   +3 more
doaj   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source