Results 41 to 50 of about 753,160 (284)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Suitable classification of mortars from ancient roman and renaissance frescoes using thermal analysis and chemometrics [PDF]

open access: yes, 2015
Background Literature on mortars has mainly focused on the identification and characterization of their components in order to assign them to a specific historical period, after accurate classification.
Campanella, Luigi   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Asiago eclipsing binaries program. I. V432 Aur

open access: yes, 2003
The orbit and physical parameters of the previously unsolved eclipsing binary V432 Aur, discovered by Hipparcos, have been derived with errors better than 1% from extensive Echelle spectroscopy and B, V photometry.
A. Siviero   +51 more
core   +1 more source

Knowledge discovery for friction stir welding via data driven approaches: Part 1 – correlation analyses of internal process variables and weld quality [PDF]

open access: yes, 2012
For a comprehensive understanding towards Friction Stir Welding (FSW) which would lead to a unified approach that embodies materials other than aluminium, such as titanium and steel, it is crucial to identify the intricate correlations between the ...
Beamish, Kathryn   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Effect of In-Process Inspection on Highly Imperfect Production System Considering Environmental Deliberations

open access: yesMathematics
The aim of almost every production firm is to gain maximum profit along with customer satisfaction. The formation of imperfect products is an obvious process in a production system, which is not a good thing from a business point of view.
Sunita Yadav   +4 more
doaj   +1 more source

Effectiveness evaluation of quota payment for specific diseases under global budget: a typical provider payment system reform in rural China

open access: yesBMC Health Services Research, 2018
Background Quota payment for specific diseases under global budget is one of the most typical modes of provider payment system reform in rural China.
Hao-miao Li   +9 more
doaj   +1 more source

THE CHANGES IN THE LEVEL OF BETA ENDORPHIN, INTERSLEUKIN-2, INTERLEUKIN-4, INTERLEUKIN-6, IMUNOGLOBULIN AND CORTISOL HORMONE ON THE PRACTICES OF SATRIA NUSANTARA [PDF]

open access: yes, 2010
The purpose of this research is to reveal the changes of immunity at breathing exercises. This is an experimental research study. This research used “randomized pretest-posttest control group design.
Sudarko, Rumpis Agus
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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