Results 71 to 80 of about 753,160 (284)

The Single Period Coverage Facility Location Problem: Lagrangean heuristic and column generation approaches [PDF]

open access: yes, 2010
In this paper we introduce the Single Period Coverage Facility Location Problem. It is a multi-period discrete location problem in which each customer is serviced in exactly one period of the planning horizon.
Albareda Sambola, María   +3 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Feedback Generation for Performance Problems in Introductory Programming Assignments

open access: yes, 2014
Providing feedback on programming assignments manually is a tedious, error prone, and time-consuming task. In this paper, we motivate and address the problem of generating feedback on performance aspects in introductory programming assignments.
Gulwani, Sumit   +2 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

PENGARUH KOMPENSASI DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN DIVISI QIP PT. GSI CIANJUR

open access: yesJurnal Ilmiah Teknik Industri, 2014
The role of human resource management is continously improved to enhance the performance of employees. PT GSI, as one of Indonesian company producing shoe products to meet demand from all around the world, needs employees with high performance.
Suharyanto Suharyanto   +2 more
doaj   +3 more sources

Ageing Assessment and Management at Major-Hazard Industries

open access: yesChemical Engineering Transactions, 2018
As a consequence of the obligations of the Directive Seveso III, there is a need of methods and tools that support industrial managers and the auditors, respectively, to manage and to verify the ageing status of critical equipment.
Francesca Milazzo Maria   +3 more
doaj   +1 more source

Effectiveness of organic certification: a study on an italian organic certificator's data. [PDF]

open access: yes, 2013
The aim of this paper is to implemnt risk-based models for the inspection procedures in the organic certification. particularly, the aim is to analyse the the relationship between the type of sanction a farm receives, and the farm's structure and ...
Gambelli, Danilo   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

MODEL FOR THE EVALUATION OF THE AIRPORT SECURITY SYSTEM [PDF]

open access: yesScientific Journal of Silesian University of Technology. Series Transport, 2014
An airport is a complex human-factors engineering system; it is composed of many elements interconnected with numerous internal relations with a strongly pronounced role of the human factor.
Jacek SKORUPSKI, Piotr UCHROŃSKI
doaj  

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