Results 121 to 130 of about 3,048,905 (395)

Permeability characteristics of fractured rock mass: a case study of the Dongjiahe coal mine

open access: yesGeomatics, Natural Hazards & Risk, 2020
The intricate distribution of fractures in rock mass leads to the anisotropy of permeability characteristics of the rock mass, which affects the overall stability of rock mass.
Ke Ma   +5 more
doaj   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Generation of Large-Scale Vorticity in a Homogeneous Turbulence with a Mean Velocity Shear

open access: yes, 2003
An effect of a mean velocity shear on a turbulence and on the effective force which is determined by the gradient of Reynolds stresses is studied. Generation of a mean vorticity in a homogeneous incompressible turbulent flow with an imposed mean velocity
A. Glasner   +40 more
core   +1 more source

The instability of studies of instability [PDF]

open access: yesJournal of Evolutionary Biology, 1997
Michael C. Whitlock, Kevin Fowler
openaire   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Critical roles of Dpb3-Dpb4 sub-complex of DNA polymerase epsilon in DNA replication, genome stability, and pathogenesis of Candida albicans

open access: yesmBio
DNA polymerase ε (Polε) is an essential replicative polymerase consisting of Pol2, Dpb2, Dpb3, and Dpb4 subunits and has not been explored in the pathogenic yeast Candida albicans. C. albicans is accountable for >40% of deaths due to systemic candidiasis
Bhabasha Gyanadeep Utkalaja   +4 more
doaj   +1 more source

Qualitative and quantitative analysis of stability and instability dynamics of positive lattice solitons

open access: yes, 2008
We present a unified approach for qualitative and quantitative analysis of stability and instability dynamics of positive bright solitons in multi-dimensional focusing nonlinear media with a potential (lattice), which can be periodic, periodic with ...
B. Crosignani   +13 more
core   +1 more source

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.

open access: yesNew England Journal of Medicine, 2003
BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of
C. Ribic   +12 more
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

open access: yesFEBS Open Bio, Volume 15, Issue 7, Page 1103-1112, July 2025.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet   +6 more
wiley   +1 more source

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