Results 121 to 130 of about 2,614,548 (357)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Hsp90-Mediated Multi-Drug Resistance in DNA Polymerase-Defective Strains of Candida albicans

Journal of Fungi
The incidence of infections caused by Candida species, specifically by drug-resistant isolates, is a major health concern as they can disseminate to and colonize most vital organs, enhancing morbidity and mortality. Several molecular mechanisms have been
Bhabasha Gyanadeep Utkalaja, Satya Ranjan Sahu, Sushree Subhashree Parida, Narottam Acharya   +3 more
doaj   +1 more source

Microsatellite instability in myeloid leukemias [letter; comment] [PDF]

, 1994
Nicholas C.P. Cross, H Silly, JM Goldman
openalex   +1 more source

Short-wavelength secondary instabilities in homogeneous and stably stratified shear flows

, 2018
We present a numerical investigation of three-dimensional, short-wavelength linear instabilities in Kelvin-Helmholtz (KH) vortices in homogeneous and stratified environments.
Aravind, H. M., Dubos, Thomas, Mathur, Manikandan   +2 more
core  

Modulational instability of two-component Bose-Einstein condensates in an optical lattice

, 2004
We study modulational instability of two-component Bose-Einstein condensates in an optical lattice, which is modelled as a coupled discrete nonlinear Schr \"{o}dinger equation.
Chul Koo Kim, G. P. Agrawal, Guang-Ri Jin, Kyun Nahm   +3 more
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Creep behaviour of sandstone under different water conditions and its response to varying impact energy

Geomatics, Natural Hazards & Risk
Creep deformation and failure of immersed sandstone under mining disturbances are critical factors driving water inrush and goaf collapse. This study employed a specialized creep-impact testing system capable of simultaneous water immersion and ...
Honglei Liu, Jianhua Zhou, Jinduo Li, Wenxue Deng, Leilei Niu, Tianhong Yang, Shixian Zhang   +6 more
doaj   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Flow instabilities of magnetic flux tubes II. Longitudinal flow

, 2007
Flow-induced instabilities are relevant for the storage and dynamics of magnetic fields in stellar convection zones and possibly also in other astrophysical contexts.
Achterberg, Achterberg, Achterberg, Andries, Andries, Andries, Cairns, Cheng, D'Silva, D. Schmitt, Ferrari, Ferriz-Mas, Ferriz-Mas, Goossens, Hollweg, Joarder, Kolesnikov, Lashmore-Davies, M. Schüssler, Moreno-Insertis, Moreno-Insertis, Nakariakov, Osin, Parker, Parker, Rae, Ray, Ryutova, Ryutova, Satya Narayanan, Schmitt, Schüssler, Spruit, Spruit, Tirry, V. Holzwarth, Walker   +36 more
core   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source