Results 41 to 50 of about 450,100 (292)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Проект БайкалThe lifespan of architectural objects varies in the widest range – from a few days to millennia. Most often a built object begins to change, to transform even before the construction is finished, and continues to do so every day of its existence.
Константин Лидин +1 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
ARQ, 2008 En el paisaje desértico de Marfa, Texas se localizan seis edificios que contienen esta instalación de tubos de luz fluorescente de Dan Flavin. Parte de su obra es descrita y explicada por el director y técnico de su estudio, profundizando en esta obra ...
Steve Morse
doaj
Coordination mechanisms for inventory control in three-echelon serial and distribution systems [PDF]
, 2004 This paper is concerned with the coordination of inventory control in three-echelon serial and distribution systems under decentralized control. All installations in these supply chains track echelon inventories.
Timmer, J.B., Zijm, W.H.M.
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Soft Pavilion: Anchorage, EE.UU.
ARQ, 2011 Evento, colectividad y atmósfera: el envío de una serie de instrucciones a distancia, la confección de cien piezas textiles por parte de un grupo de voluntarios y la celebración de tres montajes en diferentes lugares de la ciudad -como parte de una serie
Mauricio Pezo, Sofía von Ellrichshausen
doaj
The present time of transposition of the European environmental legislation into Czech food industry
Research in Agricultural Engineering, 2004 The accession of the Czech Republic in the European Union has brought a necessity to adopt a range of new legal regulations and to apply them in our conditions.
L. Macháčková, P. Heneman
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source