Results 111 to 120 of about 345,447 (283)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TSNET: A solid waste instance segmentation model in China based on a Two-Step detection strategy and satellite remote sensing images

International Journal of Applied Earth Observations and Geoinformation
Due to the concealment and randomness of solid waste disposal sites, the time and manpower costs for manual on-site inspections or remote sensing visual interpretation are significantly increased.
Jiaqi Yu, Pan Mao, Wenfu Wu, Qingtao Wang, Xiang Shao, Jiahua Teng, Yifei Wang   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PlantSegNeRF: A few-shot, cross-species method for plant 3D instance point cloud reconstruction via joint-channel NeRF with multi-view image instance matching

Artificial Intelligence in Agriculture
Organ segmentation of plant point clouds is a prerequisite for the high-resolution and accurate extraction of organ-level phenotypic traits. Although the fast development of deep learning has boosted much research on segmentation of plant point clouds ...
Xin Yang, Ruiming Du, Hanyang Huang, Jiayang Xie, Pengyao Xie, Leisen Fang, Ziyue Guo, Nanjun Jiang, Yu Jiang, Haiyan Cen   +9 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

One-Shot Instance Segmentation

, 2018
We tackle the problem of one-shot instance segmentation: Given an example image of a novel, previously unknown object category, find and segment all objects of this category within a complex scene. To address this challenging new task, we propose Siamese Mask R-CNN.
Michaelis, Claudio, Ustyuzhaninov, Ivan, Bethge, Matthias, Ecker, Alexander S.   +3 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

An Effective Strategy of Object Instance Segmentation in Sonar Images

IET Signal Processing
Instance segmentation is a task that involves pixel-level classification and segmentation of each object instance in images. Various CNN-based methods have achieved promising results in natural image instance segmentation. However, the noise interference,
Pengfei Shi, Huanru Sun, Qi He, Hanren Wang, Xinnan Fan, Yuanxue Xin   +5 more
doaj   +1 more source

Audio-Visual Instance Segmentation

2025 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR)
Accepted by CVPR ...
Guo, Ruohao, Ying, Xianghua, Chen, Yaru, Niu, Dantong, Li, Guangyao, Qu, Liao, Qi, Yanyu, Zhou, Jinxing, Xing, Bowei, Yue, Wenzhen, Shi, Ji, Wang, Qixun, Zhang, Peiliang, Liang, Buwen   +13 more
openaire   +2 more sources