Results 31 to 40 of about 169,448,468 (235)

International Conference Middle Eastern Studies in Eurasia: Oriental Studies Culture and Search for New Formats of Interaction

Концепт: философия, религия, культура, 2023
On October 20–21, 2023, the International Conference Middle Eastern Studies in Eurasia was held in Moscow, organized by the Primakov Center and the Institute of Oriental Studies of the Russian Academy of Sciences.
M. A. Sapronova
doaj   +1 more source

Tell el-Retaba (West): season 2019 [PDF]

Polish Archaeology in the Mediterranean, 2020
Area 4 north of the Migdol was the focus of the 2019 season excavations. An apparent well from Phase G3 was discovered with some pottery sherds inside dating from the end of the Middle Kingdom.
Jozef Hudec, Veronica Dubcova, Lucia Hulkova, Anna Wodzińska   +3 more
doaj   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

THE PALESTINIAN PROBLEM IN THE MIDDLE EAST POLICY OF THE USSR / RUSSIA

Vestnik MGIMO-Universiteta, 2017
The article reveals the stages in the formation of the USSR policy in the field of the Palestinian-Israeli conflict resolution, the features of the developed policy and practical conclusions that could be useful in advancing the current Middle East ...
T. V. Nosenko, V. A. Isaev, E. S. Melkumyan   +2 more
doaj   +1 more source

Results of the Study of the Sea Fortress Remains of Maraclea (Kharab Maraqiya) in the Water Area of the Syrian Arab Republic in 2021–2022

Археология евразийских степей, 2023
In January and September 2022, the studies of the Syrian-Russian underwater archaeological expedition continued in the water area of the Tartus Governorate.
Victor V. Lebedinskiy, Vitaly V. Prudnikov   +1 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Energy Transformation in China: Perspectives and Obstacles

Контуры глобальных трансформаций: политика, экономика, право, 2023
Sustainable development is the core of China’s ecological strategy which includes climate problems as its part. It means that industrial development remains an important component of ecological policy, besides, the government undertakes gigantic projects
Yu. A. Makeev, A. I. Salitskii, N. K. Semenova, Xin Zhao   +3 more
doaj   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source