Results 161 to 170 of about 1,371,709 (339)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Littérature et masque : une étude comparée de leur fonctionnement comme institutions
Tydskrif vir Letterkunde, 2019 Le fonctionnement de la littérature comme une institution est connu et a été suffisamment développé dans les études littéraires ; cela a permis aux différents théoriciens de définir l’institution et de montrer l’autonomie du champ littéraire producteur ...
Salaka Sanou
doaj
Adult Education in Transition: A Study of Institutional Insecurity.
, 1957 Ward S. Mason, Burton R. Clark
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, 2013 Ce texte porte sur les élections des maires, la collecte des impôts, le clergé et les instituteurs tant durant la dernière période de l’empire ottoman que dans le royaume de Grèce.
openaire +2 more sources
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Forum: Qualitative Social Research, 2008 The theoretical focus of this article which is based on empirical findings of a biographical study about women in leadings positions in social welfare in East Germany is on the relationship between biography and institution.
Martina Schiebel
doaj
Review of American birds in the Museum of the Smithsonian Institution. Part 1
, 1872 Spencer Fullerton Baird
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The Engines of the Human Body: Being the Substance of Christmas Lectures Given at the Royal Institution of Great Britain, Christmas, 1916–1917 [PDF]
, 1920 C. L. E.
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Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source