Results 171 to 180 of about 7,375,497 (316)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Multi-Institutional Drug Use Patterns in Hospitalized Older Patients: Retrospective Cross-Sectional Study. [PDF]

JMIR Med Inform
Lee CC, Kim GJ, Kim S, Hong JY, Hwang WM, Kim JY, Lee KH, Kim K, Kang M, Kim JH, Lee S.   +10 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Treatment gaps in guideline-directed medical therapy for HFrEF in Singapore: findings from a multicentre retrospective cohort study. [PDF]

BMJ Open
Senanayake S, Lee ASY, Graves N, Win PPS, Lee A, Lau YH, Hausenloy DJ, Yeo KK, Chan MY, Wong RCC, Loh SY, Sim KLD, Chow W, Tan KB, Kularatna S.   +14 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

O psicólogo ecológico no contexto institucional: uma experiência com meninas vítimas de violência

Psicologia: Ciência e Profissão
Este ensaio consiste em um relato da experiência de trabalho de um psicólogo ecológico em uma instituição para meninas vítimas de violência, embasada no Modelo Ecológico de Desenvolvimento Humano.
Clarissa De Antoni, Silvia Helena Koller
doaj  

"Don't know" scores should be considered when assessing violence risk for youth in acute institutions. [PDF]

Front Psychiatry
Laake ALW, Roaldset JO, Husum TL, Bjørkly SK, Gustavsen CC, Grenabo ST, Lockertsen Ø.   +6 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Les institutions et les exigences paradoxales de la modernité

Trivium, 2021
Jean-François Kervégan, Christian Schmidt, Benno Zabel   +2 more
doaj   +1 more source

Sustaining grant-funded programs: Conditions for sustaining initiatives that enhance diversity in STEMM. [PDF]

PLoS One
Stephen NA, Cobian KP, Romero AL, Ramos HV, Hurtado S.   +4 more
europepmc   +1 more source