C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
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Clinical and Morphological Features of ER-Positive HER2-Negative Breast Tumors with PIK3CA Mutations in Russian Patients. [PDF]
Sokolova TN+87 more
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An outline for institutional education and treatment of young offenders. [PDF]
William Healy, Augusta F. Bronner
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Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
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Transperitoneal Multiport Robotic Partial Nephrectomy for Hilar Tumors: Step by Step. [PDF]
Banerjee I, Robinson J, Banerjee I.
europepmc +1 more source
Fierville's Quintilian - M. F. Quintiliani de Institutions Oratoria Liber Primus. Texte Latin, publié avec des notes biographiques sur Quintilien, l'histoire de l'institution oratoire et de ses abreges, la classification et la description des manuscrits, le texte abrégé par Étienne de Rouen et par Jean Racine, des notes critiques, les variantes principales et deux facsimile de manuscrits par Ch. Fierville. Paris : Firmin-Didot et Cie. 1890. f. 10. [PDF]
William Peterson
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Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
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Correction: Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model. [PDF]
Li Y+8 more
europepmc +1 more source
XX.—Communications from the Laboratory of the London Institution. On the action of potassic sulphite on the haloïd derivatives of phenol [PDF]
HENRY E. ARMSTRONG, George Harrow
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