Results 41 to 50 of about 527,927 (245)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
O Ambiente Institucional na Viticultura do município de Jales-SP [PDF]
Revista IDEAS, 2011 The production process of table grape in the Northwest region of São Paulo began in the 60s and today presents itself as an activity of big importance, this activity is an alternative of work and income generation for small scale producers.
Elisabeth de Souza Andrade +3 more
doaj
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Specifying and reasoning with institutional agents [PDF]
Proceedings of the 9th international conference on Artificial intelligence and law - ICAIL '03, 2003 This paper proposes a logic-oriented framework for institutional agents specification and analysis. Within this framework institutional agents are seen as artificial agents that aggregate a set of (real) agents, being capable to act (by means of real agents actions) and to whom deontic qualifications may be associated.
Filipe Santos, Olga Pacheco
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Agents, Markets, Institutions, and Protocols
, 2001 Thinking about agent mediated electronic commerce usually two situations come to one’s mind. The first is agents that shop on the Internet and find the best bargain (Jango (http://www.jango.com/) (Doorenbos et.al., 1996), Bargainfinder (http://bf.cstar.ac.com), etc.) and the second is that of electronic marketplaces where agents can buy and/or sell ...
openaire +2 more sources
Modelling Agent Societies: Co-ordination Frameworks and Institutions [PDF]
, 2001 Organisations can be defined as a set of entities regulated by mechanisms of social order and created by more or less autonomous actors to achieve common goals. Multi-agent systems are a natural choice to design organisational systems due to the proactive and autonomous behaviour of agents.
Dignum, F.P.M., Dignum, M.V.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Institutional Corruption and the Rule of Law
Les Ateliers de l’Ethique, 2014 The literature contains two concepts of corruption which are often confused with one another: corruption as twisted character (pollution), and corruption as disloyalty.
Paul Gowder
doaj +1 more source