Results 101 to 110 of about 40,091,927 (307)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
A Generic Four-step Methodology For Institutional Analysis [PDF]
The central hypothesis of this paper is that there may be situations in which the traditional approach to institutional analysis is of limited applicability.
Herrera, Paul A. +2 more
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Governing atmospheric sinks: the architecture of entitlements in the global commons
International Journal of the Commons, 2008 This article revisits key works on the management of common-pool resources under common property arrangements, in order to elicit a broader notion of collective ownership for analysing institutional arrangements that govern the use of large-scale ...
Jouni Paavola
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Unpacking the "institutional portfolio" theoretical elements for an analysis of institutional change through objectification of resources and habitus [PDF]
The "social kill" (Fligstein, 1997 and 2001) attributed to social entrepreneurs is ont sufficiently explicit as regards their dispositions for engaging in actions of change. After placing the status of change in the context of institutionalist literature,
Viale, Thierry
core
Part 3, Section 3.3.1: Institutional Effectiveness [PDF]
, 2011 Compliance report statement of institutional effectiveness.The institution identifies expected outcomes, assesses the extent to which it achieves these outcomes, and provides evidence of improvement based on analysis of the results in each of the ...
core +1 more source
Systems, 2019 This paper aims to show that sustainable behavior by firms may be impaired by regulatory restrictions. We challenge the assumption that regulation aimed at curbing greenhouse gas emissions (GHG) in the form of a target to meet the Country’s GHG ...
Antonio Lloret +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
An institutional analysis of strategic posture
, 2008 [Abstract]: This paper investigates the role of formal and informal institutions in shaping the strategic posture of mico, small, and medium enterprises (MSMEs).
Roxas, Banjo G.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source