Results 111 to 120 of about 26,113,156 (202)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Household Matters: On the Usefulness of an Institutional Approach for Understanding Intrahousehold Allocation [PDF]

open access: yes
This paper presents findings from a study testing the alternative of an institutional approach to model intrahousehold allocative behavior. It argues that the income-pooling test and the conventional neoclassical household models only capture part of ...
Holvoet, Nathalie
core  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

open access: yesAging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho   +4 more
wiley   +1 more source

ANTI-CRISIS MANAGEMENT OF THE RUSSIAN HEAVY ENGINEERING INDUSTRY: INSTITUTIONAL APPROACH

open access: yesRussian Journal of Economics and Law, 2013
Objective: to elaborate the measures of anti-crisis management of the Russian heavy engineering industry. Method: abstract-logical. Results: basing on the revealed problems in the Russian heavy engineering industry, the necessity to solve them is proved.
D. V. Manushin
doaj  

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

open access: yesAging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara   +3 more
wiley   +1 more source

PREREQUISITES AND DIRECTIONS OF INTEGRATION IN RUSSIAN EDUCATION

open access: yesRussian Journal of Economics and Law, 2013
The article views integration mechanisms in the Russian educational system, which are aimed at increasing its efficiency and competitiveness under the given conditions of economic systems development.
A. V. Timiryasova, T. V. Kramin
doaj  

A study of major institutional repositories in India [PDF]

open access: yes, 2009
Institutional repositories (IR) are digital collections that capture, collect, manage, disseminate, and preserve scholarly work created by the constituent members in individual institutions.
Lihitkar, Ramdas, Lihitkar, Shalini
core  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

INFLUENCE OF A LARGE-SCALE INTERNATIONAL SPORTS EVENT ON THE SOCIAL-ECONOMIC DEVELOPMENT OF A HOST REGION

open access: yesRussian Journal of Economics and Law, 2012
The article presents a brief summary of examples of social-economic consequences of hosting large-scale international competitions. By the example of Universiade-2013 in Kazan the author shows the influence of a large-scale international sports event on ...
V. A. Leonov
doaj  

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy