Results 131 to 140 of about 17,423,018 (283)

Reforming delivery of urban services in developing countries: Evidence from a case study in India. [PDF]

Given the importance of urban public services in attracting firm location, increasing employment and facilitating economic growth, in this paper, we examine the following questions: Is there a need for reforming public service delivery in Ludhiana (which
Sridhar, Kala Seetharam
core  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Beyond Bureaucracy? Assessing Institutional Change in the Governance of Water in England

Water Alternatives, 2009
Alternative governance approaches in which non-state actors play a substantial role in policy making and implementation are currently attracting attention. Government-centred water bureaucracies have to adapt to increased complexity.
Nigel Watson, Hugh Deeming, Raphael Treffny   +2 more
doaj  

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Re-Examining the Regulatory Frameworks and Institutional Arrangements for Strategic Management of Public Service in The Gambia

Ilorin Journal of Administration and Development
This paper assessed the regulatory frameworks and institutional arrangements for strategic management of public service in The Gambia. The study reviewed and analysed policy documents related to the regulatory frameworks and institutional arrangements ...
Banna Sawaneh, Taiwo A. Olaiya
doaj  

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

A multisectoral institutional arrangements approach to integrating civil registration, vital statistics, and identity management systems. [PDF]

J Health Popul Nutr, 2019
Mills S, Lee JK, Rassekh BM.
europepmc   +1 more source

Modular Metamaterials for Adaptable MRI Signal Control: Combining Dipole Array With a New Hexagon‐Based Artificial Dielectrics

Advanced Science, EarlyView.
A flexible, hexagonally packed artificial dielectric providing a wide range of effective permittivities (εr ≈ 30–1400) without lumped elements was developed for clinical and ultra‐high‐field MRI. Combined with modular passive‐dipole arrays, the system enables adaptable RF field shaping through electric‐ and magnetic‐dipole tuning.
Santosh Kumar Maurya, Ilan Goldberg, Rita Schmidt   +2 more
wiley   +1 more source